Debljina, metabolički sindrom i kardiovaskularni rizik

master's thesis

• Title (english): Obesity, metabolic syndrome and cardiovascular risk
• Author: Jana Car
• Mentor: Sandra Jakšić Jurinjak (mentor)
• Committee member: Jadranka Šeparović Hanževački (predsjednik povjerenstva)
• Committee member: Martina Lovrić Benčić (član povjerenstva)
• Committee member: Sandra Jakšić Jurinjak (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Incidencija prekomjerne tjelesne teţine sve je veća i predstavlja veliki javnozdravstveni problem u cijelom svijetu. Prema Svjetskoj zdravstvenoj organizaciji prekomjerna tjelesna teţina definira se kod osoba ĉiji je ITM veći od 25 kg/m². Ĉak 2 milijarde ljudi u svijetu boluje od prekomjerne tjelesne teţine ili pretilosti. Pretilost moţemo podijeliti na više razliĉitih vrsta, a kliniĉki nas najviše zabrinjava tzv. visceralna pretilost. Ĉesta posljedica pretilosti je razvoj metaboliĉkog sindroma. To je naziv za skup poremećaja koji ukljuĉuju poremećaj regulacije masti u tijelu, neosjetljivost na inzulin, povišen krvni tlak, te visceralni tip debljine. Postoje razliĉiti kriteriji kojima se dijagnosticira metaboliĉki sindrom i njegova definicija nije još u potpunosti usuglašena. Dijagnostiĉke kriterije izradili su Svjetska zdravstvena organizacija (SZO), MeĊunarodna federacija za dijabetes (IDF) i sudionici Nacionalnog programa obrazovanja o kolesterolu Panel lijeĉenja za odrasle III (NCEP ATP III). Metaboliĉki sindrom osim što znatno utjeĉe na kvalitetu ţivota, ĉini veliko opterećenje za zdravstveni sustav, te je povezan s incidencijom kardiovaskularnih bolesti koje su i dalje vodeći uzrok mortaliteta i morbiditeta u razvijenim zemljama svijeta, bez obzira na sve bolje ishode lijeĉenja. Upravo iz tog razloga njihova pravodobna dijagnostika i prevencija od iznimne je vaţnosti. Postoji više naĉina predviĊanja razvoja kardiovaskularnih bolesti u narednih 10 godina kod pacijenata s obzirom na razliĉite parametre, a kliniĉki najznaĉajniji su Framinghamske tablice rizika, QRISK3 (Cardiovascular risk score), ASSIGN i SCORE2. Cilj ovog rada bio je saţeti do sada poznato, te pokazati povezanost izmeĊu ova tri kliniĉki iznimno vaţna entiteta od kojih boluje veliki broj ljudi u svijetu.

Abstract (english)

The incidence of obesity is increasing and represents a major public health problem worldwide. According to the World Health Organization, obesity is defined in people whose BMI is greater than 25 kg / m2. Around 2 billion people worldwide suffer from overweight or obesity. Obesity can be divided into several different types, and clinically we are most concerned about the so-called ''visceral'' obesity. A common consequence of obesity is the development of metabolic syndrome.This reffers to the set of disorders that include a disorder of body fat regulation, insulin insensitivity, high blood pressure and visceral type obesity. There are various criteria for diagnosing metabolic syndrome and its definition is not yet fully agreed. The diagnostic criteria were developed by the World Health Organization (WHO), the International Diabetes Federation (IDF) and participants in the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). In addition to significantly affecting the quality of life, metabolic syndrome significantly burdens the overall health system and is associated with the incidence of cardiovascular diseases that continue to be the leading cause of mortality and morbidity in developed countries, despite the improving treatment outcomes. That's why their timely diagnosis and prevention is of utmost importance. There are several ways to predict the development of cardiovascular diseases in the next 10 years in patients with regard to various parameters. The most clinically significant are Framingham risk tables, QRISK3 (Cardiovascular risk score), ASSIGN and SCORE2. The aim of this paper was to summarize previous knowledge and to show the connection between these three clinically extremely important entities that afflict a large number of people worldwide.

• Keywords: debljina; metaboliĉki sindrom; kardiovaskularni rizik
• Keywords (english): obesity; metabolic syndrome; cardiovascular risk
• Language: croatian
• URN:NBN: urn:nbn:hr:105:899461
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-04 10:40:39