Povezanost debljine i osteoartritisa kuka i koljena

master's thesis

• Title (english): The association of obesity with osteoarthritis of hip and knee
• Author: Lucija Cugovčan
• Mentor: Nadica Laktašić Žerjavić (mentor)
• Committee member: Porin Perić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Nadica Laktašić Žerjavić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Physical Medicine and General Rehabilitation); Zagreb
• Defense date and country: 2022-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Physical Medicine and Rehabilitation

Abstract

Osteoartritis, kao degenerativna reumatska bolest daleko je najčešći oblik artritisa i glavni uzrok boli, nesposobnosti i invaliditeta kod starijih ljudi. Karakterizira ga žarišni gubitak zglobne hrskavice, subhondralna osteoskleroza, stvaranje osteofita na rubu zgloba i remodeliranje oblika zgloba s koštanim uvećanjem zahvaćenih zglobova, hipotrofija okolnih mišića i hipertrofija okolnog masnoh tkiva. Sinovitis u osteoartrotisu najčešće se ne očituje klinički, no značajno pridonosi boli i naredovanju osteoartritisa. Koljeno je najčešće zahvaćeni zglob, a nakon njega slijedi kuk. Dijagnoza se prvenstveno postavlja klinički, a klasična radiološka i laboratorijska obrada nije potrebna osim u bolesnika s atipičnim očitovanjem. Liječenje osteoartritisa kuka i koljena dijeli se na nefarmakološko, farmakološko i kirurško. Debljina je kronična bolest povezana s povišenim mortalitetom, a zahvaća gotovo svaki organ i tkivo u tijelu. Pretilost je kao značajan sustavni i lokalni čimbenik rizika za osteoartritis uz najčvršću povezanost s osteoartritisom koljena i jedan je od rijetkih promjenjivih čimbenika rizika za pojavu i napredovanje osteoartritisa.

Abstract (english)

Osteoarthritis, a degenerative rheumatic disease, is by far the most common form of arthritis and the main cause of pain, impairment and disability in older people. It is characterized by focal loss of articular cartilage, subchondral osteosclerosis, formation of osteophytes at the edge of the joint and remodelling of the shape of the joint with bony enlargement of the affected joints, hypotrophy of the surrounding muscles and hypertrophy of the surrounding fat tissue. Synovitis in osteoarthritis is usually not manifested clinically, but it significantly contributes to the pain and advancement of osteoarthritis. The knee is the most affected joint, followed by the hip. The diagnosis is primarily made clinically, with both conventional radiography and laboratory work-up not necessary except in patients with atypical manifestations. Treatment of hip and knee osteoarthritis is divided into non-pharmacological, pharmacological and surgical. Obesity is a chronic disease associated with increased mortality, and it affects almost every organ and tissue in the body. It is a significant systemic and local risk factor for osteoarthritis with the strongest association with knee osteoarthritis and is one of the few modifiable risk factors for the onset and progression of osteoarthritis.

• Keywords: osteoartritis; debljina; koljeno; kuk
• Keywords (english): osteoarthritis; obesity; knee; hip
• Language: croatian
• URN:NBN: urn:nbn:hr:105:688216
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-04 12:24:55