Liječenje kroničnog makularnog edema

master's thesis

• Title (english): Treatment of chronic macular edema
• Author: Damir Mulc
• Mentor: Tomislav Jukić (mentor)
• Committee member: Damir Katušić (predsjednik povjerenstva)
• Committee member: Miro Kalauz (član povjerenstva)
• Committee member: Tomislav Jukić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Ophthalmology and Optometry); Zagreb
• Defense date and country: 2014-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Ophthalmology

Abstract

Makula je specijalizirano područje retine koje zbog gustoće receptora i nedostatka krvnih žila omogućuje čovjeku najjasniji vid, tj. to je područje na koje u konačnici pada središnja zraka svjetlosti nakon ulaska u oko. Sukladno svojoj kompleksnosti i najmanja patološka stanja mogu uzrokovati oštećenja centralnog vida, dok degenerativne promjene na makuli predstavljaju glavni uzrok sljepoće u svijetu. Edem makule kao vodeći patološki entitet predstavlja trajan izazov u stvaranju učinkovitije i sigurnije terapije. Dosadašnje metode uporabe nesteroidnih antireumatika i kortikosteroida nadišle su topičku primjenu i otvorile nove mogućnosti u vidu intravitrealnih injekcija. Primjena acetazolamida takoĎer je našla svoje mjesto kao oblik konzervativnog liječenja, dok s druge strane kirurški pristup omogućava alternativu ili terapiju izbora kod pratećih oštećenja retine i vitreusa. Laser fotokoagulacija je metoda koja daje zadovoljavajuće rezultate i predstavlja zlatni standard u liječenju, prvenstveno dijabetičkog makularnog edema i dijabetičke retinopatije. U novije vrijeme uporaba anti-VEGF terapije pokazuje izvanredne rezultate i njena bi standardna primjena u kombinaciji s laser fotokoakulacijom predstavljala budućnost liječenja dijabetičkog makularnog edema.

Abstract (english)

Macula is a specialized area of retina which high density of photoreceptors and lack of blood vessels enable high visual acuity, respectively, an area on which ultimately falls the central ray of light after entering the eye. In accordance with its complexity the most insignificant pathological states can affect the central vision acuity, while degenerative changes on macula represent the world's main cause od blindness. Macular edema as the leading pathological entity represents enduring challenge in creating more effective and more safer therapy. Previous methods of non-steroid and corticosteroid use have overcome the topical application and have opened new opportunities in the form of intravitreal injections. Acetazolamid use has also found its place as a form of conservative type of therapy, while, at the other hand, surgical access provides an alternative or a therapy of choice in states associated with retina or vitreus injury. Laser photocoagulation is a metod which gives satisfactory results and represents a golden standard, primarily diabetic macular edema and diabetic retinopathy therapy. Recently, the use of anti-VEGF therapy showes outstanding results and her sandard use in combination with laser fhotocoagulation would represent the future of diabetic macular edema therapy.

• Keywords: makularni edem; laser fotokoagulacija; anti-VEGF; pars plana vitrektomija; intravitrealna injekcija
• Keywords (english): macular edema; laser photocoagulation; anti-VEGF; pars plana vitrectomy; intravitreal injection
• Language: croatian
• URN:NBN: urn:nbn:hr:105:756043
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-03-14 13:30:14