Novel micro-MRI approach for subchondral trabecular bone analysis in patients with hip osteoarthritis is comparable to micro-CT approach

Scientific paper - Original scientific paper

• Author: Tea Duvančić
• Author: Siniša Škokić
• Author: Igor Erjavec
• Author: Mihovil Plečko
• Author: Ivan Bohaček
• Author: Srećko Gajović
• Author: Domagoj Delimar
• Author's institution: University of Zagreb; School of Medicine; (Croatian Institiute for Brain Research)
• Author's institution: University of Zagreb; School of Medicine; (Department of Anatomy and Clinical Anatomy)
• Author's institution: University of Zagreb; School of Medicine; (Department of Histology and Embryology)
• Author's institution: University of Zagreb; School of Medicine; (Department of Orthopedics)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Cytology, Histology and Embryology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Neuroscience
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Orthopedics
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Anatomy

Abstract (english)

Aim: To test the agreement between a newly developed micro-magnetic resonance imaging (MRI) analysis of the subchondral bone and the micro-computed tomography (CT) approach.
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Methods: Samples obtained from 10 patients with osteoarthritis undergoing total hip arthroplasty were scanned with a 7.0 T micro-MRI. Proton density-weighted images and proton density-weighted images with fat suppression were obtained. The results were validated with a micro-CT device. Micro-MRI and micro-CT scans of the same sample were aligned, and regions of interest were delineated on equal areas of the sample. Bone volume fraction was calculated by using in-house plugins. The agreement between the methods was tested with Bland-Altman analysis.
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Results: The agreement between the methods was good, with average difference of 2.167%. The differences between the methods were not significant (P=0.272, t test).
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Conclusion: The novel micro-MRI approach could be used for subchondral bone analysis. With further optimization for clinical MRI machines, the approach can be also used in the diagnostics of hip osteoarthritis.

• Keywords (english): Cancellous Bone; Humans; Magnetic Resonance Imaging; Osteoarthritis, Hip / diagnostic imaging; Osteoarthritis, Hip / surgery; Protons; X-Ray Microtomography / methods
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Croatian Medical Journal
• Numbering: vol. 63, no. 6, pp. 515-524
• p-ISSN: 0353-9504
• e-ISSN: 1332-8166
• DOI: https://doi.org/10.3325/cmj.2022.63.515
• URN:NBN: urn:nbn:hr:105:065850
• Publication: 2022-12-31
• Document URL: http://www.cmj.hr/2022/63/6/36597563.htm
• Type of resource: Text
• Access conditions: Open access
• Created on: 2023-01-16 12:37:10