Liječenje hemolitičko uremijskog sindroma ekulizumabom ili ravulizumabom

master's thesis

• Title (english): Treatment of hemolytic-uremic syndrome with eculizumab or ravulizumab
• Author: Matija Matošević
• Mentor: Ivana Vuković Brinar (mentor)
• Committee member: Ana Boban (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Ivana Vuković Brinar (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Hemolitičko-uremijski sindrom predstavlja tešku i rijetku skupinu bolesti čije je zajedničko, osnovno patološko obilježje pojava trombotičke mikroangiopatije. Hemolitičko-uremijski sindrom karakterizira trijas koji uključuje perifernu trombocitopeniju, mehaničku hemolitičku anemiju i ozljedu organa, prvenstveno bubrega i mozga. Postoje brojne klasifikacije, ali danas je najčešća klasifikacija Međunarodnog društva za hemolitičko-uremijski sindrom iz 2016. godine.. Posebno treba istaknuti atipični hemolitičko-uremijski sindrom, zbog njegove opširne genetske podloge i etiologije vezane uz sustav komplementa. Klinička slika ovisi o uzroku same bolesti, kao i pristup dijagnostici i liječenju. Ekulizumab i ravulizumab monoklonska su protutijela koja blokiraju C5 komponentu komplementa te se koriste u liječenju atipičnog hemolitičko uremijskog sindroma. Svrha ovog rada je napraviti pregled hemolitičko-uremijskog sindroma, s posebnim naglaskom na atipični hemolitičko-uremijski sindrom i njegovo liječenje monoklonskim protutijelima ekulizumabom i ravulizumabom uz usporedbu ove dvije terapije.

Abstract (english)

Hemolytic-uremic syndrome is a severe and rare group of diseases whose common, basic pathological feature is the occurrence of thrombotic microangiopathy. Hemolytic-uremic syndrome is characterized by a triad that includes peripheral thrombocytopenia, mechanical hemolytic anemia, and injury to organs, primarily kidney and brain. There are numerous classifications, but today the most common classification is the International Society for Hemolytic-Uremic Syndrome from 2016. Special emphasis should be put on atypical hemolytic-uremic syndrome, due to its extensive etiological and genetic background related to the complement system. The clinical presentation as well as the approach to diagnosis and treatment depends on the cause of the disease itself. Eculizumab and ravulizumab are monoclonal antibodies that block the C5 component of complement and are used to treat atypical hemolytic-uremic syndrome. The purpose of this paper is to review hemolytic-uremic syndrome, with special emphasis on atypical hemolytic-uremic syndrome and its treatment with monoclonal antibodies eculizumab and ravulizumab, with special emphasis on the comparison of two drugs.

• Keywords: Hemolitičko-uremijski sindrom; liječenje
• Keywords (english): Hemolytic-uremic syndrome; treatment
• Language: croatian
• URN:NBN: urn:nbn:hr:105:314397
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-19 09:36:05