Uzročnici septičkih pobačaja i ranih prijevremenih poroda u Kliničkoj bolnici "Sveti Duh" u periodu od 2016.-2020.

master's thesis

• Title (english): Microbiological causes of septic abortion and preterm birth at the Clinical Hospital "Sveti Duh" in the period from 2016-2020
• Author: Ana Oklobdžija
• Mentor: Vladimir Blagaić (mentor)
• Committee member: Tatjana Pavelić Turudić (predsjednik povjerenstva)
• Committee member: Dinka Pavičić Baldani (član povjerenstva)
• Committee member: Vladimir Blagaić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Septički pobačaj je značajan zdravstveni problem s kratkotrajnim, ali i dugotrajnim komplikacijama koje u velikoj mjeri utječu na daljnju kvalitetu života trudnice. Prijevremeni porod glavni je uzrok neonatalne smrtnosti i morbiditeta u cijelom svijetu. Bakterijska infekcija i naknadni upalni odgovor prepoznati su kao važan uzrok prijevremenog poroda. Pretpostavlja se da u većini slučajeva mikroorganizmi invadiraju maternicu putem cervikalnog kanala, koloniziraju plodove ovoje i posteljicu te uzrokuju korioamnionitis, a u pojedinim slučajevima inficiraju i fetus.
Cilj ovog rada bio je ustanoviti najčešće mikrobiološke uzročnike spontanih septičkih pobačaja i ranih prijevremenih porođaja u Kliničkoj bolnici „Sveti Duh“ u periodu od 1. siječnja 2016. do 31. prosinca 2020. godine. U istraživanje su bile uključene pacijentice sa dijagnosticiranim spontanim septičkim pobačajem i ranim prijevremenim porodom kojima je mikrobiološki obrađena posteljica, plodovi ovoji, plodna voda i pupkovina. Sveukupno je iz navedenih uzoraka izolirano 44 vrste mikrobioloških uzročnika. Najčešće izolirani uzročnici pri spontanom septičkom pobačaju su Enterococcus faecalis (54%) Escherichia coli (43%) BHS-B (32%) Klebsiella pneumoniae (16%) i Candida albicans (10%). Međutim najčešće izolirani uzročnici u ranim prijevremenim porodima su Escherichia coli (60%), Enterococcus faecalis (44%), BHS-B (31%), Ureaplasma urealyticum (20%) i Klebsiella pneumoniae (18%).

Abstract (english)

Septic abortion is an important and serious health problem with short-term and long-term complications that affect the further quality of life of pregnant women. Preterm birth is a serious health and social problem, also a major cause of neonatal death and morbidity worldwide. Bacterial infection and subsequent inflammatory response have been identified as an important cause of preterm birth.
The aim of this study was to identify the most common microbiological causes of spontaneous septic abortions and extreme and very preterm birth at the Clinical hospital "Sveti Duh" in the period from January 1, 2016 to December 31, 2020. The study included patients diagnosed with spontaneous septic abortion and extreme and very preterm birth who underwent microbiological analysis of the placenta, fetal membranes, amniotic fluid and umbilical cord. A total of 44 species of microbiological agents were isolated from these samples. The most commonly isolated pathogens in spontaneous septic abortion were Enterococcus faecalis (54%) Escherichia coli (43%) BHS-B (32%) Klebsiella pneumoniae (16%) and Candida albicans (10%). However, the most commonly isolated pathogens in early preterm birth were Escherichia coli (60%), Enterococcus faecalis (44%), BHS-B (31%), Ureaplasma urealyticum (20%), and Klebsiella pneumoniae (18%).

• Keywords: septički pobačaj; rani prijevremeni porod; mikrobiološki uzročnici
• Keywords (english): septic abortion; preterm birth; microbiological agent
• Language: croatian
• URN:NBN: urn:nbn:hr:105:690390
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-26 09:07:14