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Scientific paper - Original scientific paper
Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study
Biomedicines, 10 (2022), 9; 2175. https://doi.org/10.3390/biomedicines10092175
Lekšić, Gloria; Baretić, Maja; Gudelj, Lara; Radić, Marija; Miličić, Iva; Ivanišević, Marina; Jurišić-Eržen, Dubravka

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Lekšić, G., Baretić, M., Gudelj, L., Radić, M., Miličić, I., Ivanišević, M. & Jurišić Eržen, D. (2022). Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study. Biomedicines, 10. (9). doi: 10.3390/biomedicines10092175

Lekšić, Gloria, et al. "Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study." Biomedicines, vol. 10, no. 9, 2022. https://doi.org/10.3390/biomedicines10092175

Lekšić, Gloria, Maja Baretić, Lara Gudelj, Marija Radić, Iva Miličić, Marina Ivanišević and Dubravka Jurišić Eržen. "Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study." Biomedicines 10, no. 9 (2022). https://doi.org/10.3390/biomedicines10092175

Lekšić, G., et al. (2022) 'Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study', Biomedicines, 10(9). doi: 10.3390/biomedicines10092175

Lekšić G, Baretić M, Gudelj L, Radić M, Miličić I, Ivanišević M, and sur.. Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study. Biomedicines [Internet]. 2022 September 02 [cited 2024 April 10];10(9). doi: 10.3390/biomedicines10092175

G. Lekšić, et al., "Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study", Biomedicines, vol. 10, no. 9, September 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:225287. [Accessed: 10 April 2024]

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Metadata
Title (english)Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study
AuthorGloria Lekšić
AuthorMaja Baretić
AuthorLara Gudelj
AuthorMarija Radić
AuthorIva Miličić
AuthorMarina Ivanišević
AuthorDubravka Jurišić-Eržen
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Gynecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Pregnancies with type 1 diabetes mellitus (T1DM) have a high incidence of large-for-gestational-age neonates (LGA) despite optimal glycemic control. In recent years, glycemic variability (GV) has emerged as a possible risk factor for LGA, but the results of the conducted studies are unclear. This study analyzed the association between GV and LGA development in pregnancies with T1DM. This was a prospective cohort study of patients with T1DM who used continuous glucose monitoring (CGM) during pregnancy. Patients were followed from the first trimester to birth. GV parameters were calculated for every trimester using the EasyGV calculator. The main outcomes were LGA or no-LGA. Logistic regression analysis was used to assess the association between GV parameters and LGA. In total, 66 patients were included. The incidence of LGA was 36%. The analysis extracted several GV parameters that were significantly associated with the risk of LGA. The J-index was the only significant parameter in every trimester of pregnancy (odds ratios with confidence intervals were 1.33 (1.02, 1.73), 3.18 (1.12, 9.07), and 1.37 (1.03, 1.82), respectively. Increased GV is a risk factor for development of LGA. The J-index is a possible novel GV parameter that may be assessed in all three trimesters of pregnancy together with glycated hemoglobin and time-in-range.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 10, no. 9, 2175
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10092175
URN:NBNurn:nbn:hr:105:225287
Publication2022-09-02
Document URLhttps://www.mdpi.com/2227-9059/10/9/2175
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-02-13 13:00:32