Semaglutide might be a key for breaking the vicious cycle of metabolically associated fatty liver disease spectrum?

Scientific paper - Review paper

• Author: Maja Cigrovski Berković
• Author: Tanja Režić
• Author: Ines Bilić-Ćurčić
• Author: Anna Mrzljak
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (english)

Metabolically associated fatty liver disease (MAFLD) is a liver manifestation of metabolic syndrome potentially related to unfavorable hepatic and extrahepatic outcomes and progression to cirrhosis. Up to date, there are no approved pharmacotherapies for the treatment of MAFLD, so management focused on lifestyle interventions to encourage weight loss, and treatment of coexisting conditions is the only available option. Unfortunately, the aforementioned is often not potent enough to offer reversal or slow down hepatic inflammation and fibrosis. Glucagon-like peptide-1 receptor agonists have a favorable effect on glycemic management and weight loss of patients with type 2 diabetes mellitus and recently published data suggest their potential in MAFLD treatment. In addition, some of the agents have proven cardiovascular and renal benefits in dedicated cardiovascular outcome trials, making them an interesting therapeutic option. In this opinion review, we discuss the role of semaglutide in MAFLD.

• Keywords (english): Glucagon-like peptide-1 receptor agonists; Metabolically associated fatty liver disease; Non-alcoholic fatty liver disease; Semaglutide
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: World Journal of Clinical Cases
• Numbering: vol. 10, no. 20, pp. 6759-6768
• p-ISSN: 2307-8960
• DOI: https://doi.org/10.12998/wjcc.v10.i20.6759
• URN:NBN: urn:nbn:hr:105:322589
• Publication: 2022-07-16
• Document URL: https://www.wjgnet.com/2307-8960/full/v10/i20/6759.htm
• Type of resource: Text
• Access conditions: Open access
• Created on: 2023-02-21 08:12:10