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Scientific paper - Original scientific paper
Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?
Biomedicines, 10 (2022), 7; 1522. https://doi.org/10.3390/biomedicines10071522
Grgurević, Lovorka; Novak, Ruđer; Salai, Grgur; Hrkač, Stela; Močibob, Marko; Kovačević Vojtušek, Ivana; Laganović, Mario

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Grgurević, L., Novak, R., Salai, G., Hrkač, S., Močibob, M., Kovačević Vojtušek, I. & Laganović, M. (2022). Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?. Biomedicines, 10. (7). doi: 10.3390/biomedicines10071522

Grgurević, Lovorka, et al. "Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?." Biomedicines, vol. 10, no. 7, 2022. https://doi.org/10.3390/biomedicines10071522

Grgurević, Lovorka, Ruđer Novak, Grgur Salai, Stela Hrkač, Marko Močibob, Ivana Kovačević Vojtušek and Mario Laganović. "Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?." Biomedicines 10, no. 7 (2022). https://doi.org/10.3390/biomedicines10071522

Grgurević, L., et al. (2022) 'Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?', Biomedicines, 10(7). doi: 10.3390/biomedicines10071522

Grgurević L, Novak R, Salai G, Hrkač S, Močibob M, Kovačević Vojtušek I, and sur.. Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?. Biomedicines [Internet]. 2022 June 27 [cited 2024 December 21];10(7). doi: 10.3390/biomedicines10071522

L. Grgurević, et al., "Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?", Biomedicines, vol. 10, no. 7, June 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:556905. [Accessed: 21 December 2024]

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Metadata
Title (english)Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?
AuthorLovorka Grgurević
AuthorRuđer Novak
AuthorGrgur Salai
AuthorStela Hrkač
AuthorMarko Močibob
AuthorIvana Kovačević Vojtušek
AuthorMario Laganović
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
Chronic kidney disease (CKD) is the progressive loss of renal function. Although advances have been made in understanding the progression of CKD, key molecular events in complex pathophysiological mechanisms that mark each stage of renal failure remain largely unknown. Changes in plasma protein profiles in different disease stages are important for identification of early diagnostic markers and potential therapeutic targets. The goal of this study was to determine the molecular profile of each CKD stage (from 1 to 5), aiming to specifically point out markedly expressed or downregulated proteins. We performed a cross-sectional shotgun-proteomic study of pooled plasma across CKD stages and compared them to healthy controls. After sample pooling and heparin-column purification we analysed proteomes from healthy to CKD stage 1 through 5 participants' plasma by liquid-chromatography/mass-spectrometry. We identified 453 proteins across all study groups. Our results indicate that key events, which may later affect the course of disease progression and the overall pathophysiological background, are most pronounced in CKD stage 2, with an emphasis on inflammation, lipoprotein metabolism, angiogenesis and tissue regeneration. We hypothesize that CKD stage 2 is the tipping point in disease progression and a suitable point in disease course for the development of therapeutic solutions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 10, no. 7, 1522
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10071522
URN:NBNurn:nbn:hr:105:556905
Publication2022-06-27
ProjectNumber: KK.01.1.1.01.0008
Title (english): Reproduktivna i regenerativna medicina - istraživanje novih platformi i potencijala
Leader: Ana Katušić Bojanac
Jurisdiction: Croatia
Document URLhttps://www.mdpi.com/2227-9059/10/7/1522
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-03-14 08:42:14