prikaz prve stranice dokumenta Malignant insulinoma: Can we predict the long-term outcomes?
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Scientific paper - Review paper
Malignant insulinoma: Can we predict the long-term outcomes?
World Journal of Clinical Cases, 10 (2022), 16; 5124-5132. https://doi.org/10.12998/wjcc.v10.i16.5124
Cigrovski Berković, Maja; Ulamec, Monika; Marinović, Sonja; Balen, Ivan; Mrzljak, Anna

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Cigrovski Berković, M., Ulamec, M., Marinović, S., Balen, I. & Mrzljak, A. (2022). Malignant insulinoma: Can we predict the long-term outcomes?. World Journal of Clinical Cases, 10. (16), 5124-5132. doi: 10.12998/wjcc.v10.i16.5124

Cigrovski Berković, Maja, et al. "Malignant insulinoma: Can we predict the long-term outcomes?." World Journal of Clinical Cases, vol. 10, no. 16, 2022, pp. 5124-5132. https://doi.org/10.12998/wjcc.v10.i16.5124

Cigrovski Berković, Maja, Monika Ulamec, Sonja Marinović, Ivan Balen and Anna Mrzljak. "Malignant insulinoma: Can we predict the long-term outcomes?." World Journal of Clinical Cases 10, no. 16 (2022): 5124-5132. https://doi.org/10.12998/wjcc.v10.i16.5124

Cigrovski Berković, M., et al. (2022) 'Malignant insulinoma: Can we predict the long-term outcomes?', World Journal of Clinical Cases, 10(16), pp. 5124-5132. doi: 10.12998/wjcc.v10.i16.5124

Cigrovski Berković M, Ulamec M, Marinović S, Balen I, Mrzljak A. Malignant insulinoma: Can we predict the long-term outcomes?. World Journal of Clinical Cases [Internet]. 2022 [cited 2024 November 22];10(16):5124-5132. doi: 10.12998/wjcc.v10.i16.5124

M. Cigrovski Berković, M. Ulamec, S. Marinović, I. Balen and A. Mrzljak, "Malignant insulinoma: Can we predict the long-term outcomes?", World Journal of Clinical Cases, vol. 10, no. 16, pp. 5124-5132, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:074203. [Accessed: 22 November 2024]

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Metadata
Title (english)Malignant insulinoma: Can we predict the long-term outcomes?
AuthorMaja Cigrovski Berković
AuthorMonika Ulamec
AuthorSonja Marinović
AuthorIvan Balen
AuthorAnna Mrzljak
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Insulinomas are the most frequent type of functional pancreatic neuroendocrine tumors with a variety of neuroglycopenic and autonomic symptoms and well-defined diagnostic criteria; however, prediction of their clinical behavior and early differentiation between benign and malignant lesions remain a challenge. The comparative studies between benign and malignant cases are limited, suggesting that short clinical history, early hypoglycemia during fasting, high proinsulin, insulin, and C-peptide concentrations raise suspicion of malignancy. Indeed, malignant tumors are larger with higher mitotic count and Ki-67 proliferative activity, but there are no accurate histological criteria to distinguish benign from malignant forms. Several signaling pathways have been suggested to affect the pathophysiology and behavior of insulinomas; however, our knowledge is limited, urging a further understanding of molecular genetics. Therefore, there is a need for the identification of reliable markers of metastatic disease that could also serve as therapeutic targets in patients with malignant insulinoma. This opinion review reflects on current gaps in diagnostic and clinical aspects related to the malignant behavior of insulinoma.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWorld Journal of Clinical Cases
Numberingvol. 10, no. 16, pp. 5124-5132
p-ISSN2307-8960
DOIhttps://doi.org/10.12998/wjcc.v10.i16.5124
URN:NBNurn:nbn:hr:105:074203
Publication2022
Document URLhttps://www.wjgnet.com/2307-8960/full/v10/i16/5124.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-04-18 12:01:55