LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging

Scientific paper - Review paper

• Author: Dajana Krsnik
• Author: Tihana Marić
• Author: Floriana Bulić-Jakuš
• Author: Nino Sinčić
• Author: Ana Katušić Bojanac
• Author's institution: University of Zagreb; School of Medicine; (Department of Medical Biology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences

Abstract (english)

Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents.

• Keywords (english): Aging / genetics; Fertility / genetics; Humans; Klinefelter Syndrome / metabolism; Male; Spermatogonia / metabolism; Testicular Neoplasms / metabolism; Testis / metabolism
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: International Journal of Molecular Sciences
• Numbering: vol. 23, no. 13, 7245
• e-ISSN: 1422-0067
• DOI: https://doi.org/10.3390/ijms23137245
• URN:NBN: urn:nbn:hr:105:397288
• Publication: 2022-06-29
• Document URL: https://www.mdpi.com/1422-0067/23/13/7245
• Type of resource: Text
• Access conditions: Open access
• Created on: 2023-04-19 10:55:20