Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa

doctoral thesis

• Title (english): The effect of pentadecapeptide BPC 157 on reflux esophagitis during acute pancreatitis
• Author: Ivan Dobrić; MBZ: 10082
• Mentor: Mate Majerović (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2011-07-22, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Cilj istraživanja bio je pojava i progresija duodenogastroezofagealnog refluksa te njegova pogoršanja uslijed induciranog pankreatitisa te istraživanje potencijelnih terapijskih mogućnosti pentadekapeptida BPC 157. Do sada su u više navrata opisane sistemske komplikacije akutnog pankreatitisa. Osim opisanih, akutni pankreatitis dovodi i do komplikacija vezanih uz integritet i motilitet probavnog trakta, od kojih su do sada najčešće opisane one vezane za želudac i duodenum, dok su komplikacije na jednjaku vrlo slabo poznate.
Istraživanje je provedeno na ženkama Wistar Albino štakora. Duodenogastroezofagealni refluks induciran je implantacijom cjevčice u pilorički sfinkter, dok je akutni pankreatitis induciran podvezivanjem glavnoga žučnog voda ispred otvaranja u duodenum.
Istraženi su i opisani učinci pentadekapeptida BPC 157 na makroskopske i histološke promjene sluznice jednjaka te na tlak donjega ezofagealnog sfinktera, kao i na makroskopske, histološke i biokemijske promjene uslijed akutnog pankreatitisa. Rezultati su evaluirani nakon 24 sata.
Bez obzira na akutni pankreatitis, pentadekapeptid BPC 157 održava tonus DES, sprečava nastanak makroskopski vidljivih promjena jednjaka i oštećenja integriteta rožnatog sloja sluznice jednjaka. Bez obzira na to što je kod svih životinja došlo do pojave akutnog pankreatitisa, u tretiranih je životinja verificirana niža serumska koncentracija lipaza, a opažen je i povoljan učinak u sprečavanju nastanka edema i nekroze pankreasa.

Abstract (english)

The development of of duodenogastroesophageal reflux, it's worsening related to acute pancreatitis, and potential therapeutic effect of pentadecapeptie BPC 157 were the main goals of this research. Systemic complications of acute pancreatitis were described in numerous articles. The acute pancreatitis also badly influences digestive integrity and motility. This effects are mostly known to be developed in stomach and duodenum, while esophagus complications are poorly described and understood.
The female Wistar albino rats were used in this research. Duodenogastroesophageal reflux was induced by implanting the plastic tube through pylorus, amd acute pancreatitis by ligating main bile duct just proximally to it's entering into duodenum. The results were evaluated after 24 hours.
The effect of pentadecapeptide BPC 157 is described through the results describing macroscopical and hystological changes, the lowers esophageal sphyncter pressure, as well as macroscopic, hystologic and biochemical changes caused by acute pancreatitis.
Despite the acute pancreatitis developed, pentadecapeptide BPC 157 keeps the lower esophageal sphyncter strenght, prevents macroscopically identified esophageal changes, and protects corneal layer integrity. Although all the animals developed acute pancreatitis, the lipase serum level concentration was lower in treated animals, as well as edema and necrosis.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:185352
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 122 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 06:38:35