Pojavnost umora kao simptoma u zloćudnih bolesti

master's thesis

• Title (english): The incidence of fatigue that symptoms in malignant diseases
• Author: Nika Franceschi
• Mentor: Nikola Đaković (mentor)
• Committee member: Fedor Šantek (predsjednik povjerenstva)
• Committee member: Lidija Beketić-Orešković (član povjerenstva)
• Committee member: Nikola Đaković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Clinical Oncology); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology

Abstract

Umor je jedan od najčešćih simptoma u bolesnika sa zloćudnom bolesti. Može se javiti tijekom cjelokupnog trajanja bolesti: od dijagnoze, tijekom liječenja, a može trajati mjesecima, pa i godinama nakon završetka terapije. Prevalencija se kreće od 15% do 90% ovisno o korištenim metodama za mjerenje umora i karakteristikama bolesti i liječenja. Umor u onkoloških bolesnika značajno utječe na kvalitetu života, fizičko funkcioniranje i psihičko zdravlje. Ima jači negativni utjecaj na svakodnevni život bolesnika od ostalih simptoma povezanih sa zloćudnom bolesti. Umor također može imati negativan učinak na ishod liječenja smanjujući preživljenje, stoga je neophodno rano otkrivanje i odgovarajuća intervencija. Ipak simptom umora u ovih bolesnika kontinuirano je zanemaren, nedovoljno prijavljen i liječen. Uzroci umora u bolesnika sa zloćudnom bolesti su multifaktorijalni i slabo razjašnjeni, i njegova terapija često stvara velike poteškoće liječnicima i bolesnicima. S obzirom na to da je umor subjektivan simptom, najbolje se može procijeniti s pomoću upitnika koje ispunjavaju sami bolesnici. Specifično liječenje provodi se ako su identificirani uzrok ili pridonoseći čimbenici. Nespecifično liječenje umora uključuje nefarmakološke metode poput psihosocijalnih intervencija, tjelesne aktivnosti, terapije poremećaja spavanja, akupunkture i joge, dok farmakološko liječenje uključuje psihostimulanse, antidepresive i kortikosteroide. Ovaj rad predstavlja pregled prevalencije, patogeneze, dijagnostike i mogućeg liječenja simptoma umora u bolesnika sa zloćudnom bolesti.

Abstract (english)

Fatigue is one of the most prevalent symptoms in cancer patients. It can occur at any time throughout the course of the disease: at time of diagnosis, during treatment and even months to years after completion of therapy. Prevalence estimates have ranged from 15% to 90% of all cancer patients, depending on methods used for measuring fatigue and patient group characteristics. Cancer-related fatigue (CRF) has an adverse effect on quality of life, physical functioning and can significantly affect daily activities, in some cases more than any other cancer-related symptom. It can also be a risk factor for reduced survival so awareness, early diagnosis and effective intervention are necessary. Despite its impact on patients and caregivers, fatigue is underreported and underrecognized, and remains undertreated among patients with cancer. The causes of CRF are multifactorial and poorly understood. This is the why alleviating CRF is a challenge for physicians and patients. Management of fatigue is cause-specific when conditions known to contribute to fatigue can be identified and treated. Otherwise treatment modalities for CRF are nonspecific and include nonpharmacologic interventions such as psychosocial interventions, exercise, sleep therapy, acupuncture and yoga, while pharmacologic interventions include psychostimulants, antidepressants and corticosteroids. This paper focuses on prevalence, pathogenesis, assessment and possible treatment of cancer-related fatigue.

• Keywords: umor; zloćudna bolest; kvaliteta života
• Keywords (english): fatigue; cancer; quality of life
• Language: croatian
• URN:NBN: urn:nbn:hr:105:187973
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-04-01 09:45:37