Epidemiologija astme u Republici Hrvatskoj

master's thesis

• Title (english): Epidemiology of asthma in Republic of Croatia
• Author: Dominik - Mate Čutura
• Mentor: Nataša Antoljak (mentor)
• Committee member: Zdenko Sonicki (predsjednik povjerenstva)
• Committee member: Sanja Musić Milanović (član povjerenstva)
• Committee member: Nataša Antoljak (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Medical Statistics, Epidemiology and Medical Informatics); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Epidemiology

Abstract

Astma je kronična upalna bolest dišnih puteva. Kliničke manifestacije bolesti su odraz pojačanog intenziteta upale. Astma je vrlo heterogena bolest. Smatra se kako je uvjetovana kombinacijom genetskih i okolišnih čimbenika. Temeljne patogenetske karakteristike astme su upala dišnih puteva i hiperreaktivnost bronha. Klinička slika i simptomi su promjenjivi. U astmi se izmjenjuju razdoblja potpune odsutnosti simptoma sa egzacerbacijama bolesti. U dijagnostici astme se rabe brojni testovi, no nijedan nije dovoljno osjetljiv i specifičan. Testovi plućne funkcije imaju najveće značenje u postavljanju dijagnoze i procijeni težine astme. Liječenje astme zahtijeva opsežan plan koji uključuje opće mjere, farmakoterapiju i edukaciju bolesnika. Kortikosteroidi su smatrani najkorisnijim lijekovima za kontrolu bolesti, a beta2–agonisti kratkog djelovanja su najčešće korišteni lijekovi za trenutno olakšanje simptoma. Liječenje se provodi prema GINA smjernicama. Astma je jedna od najčešćih kroničnih bolesti u svijetu. Procjenjuje se da je 2011. Godine 250 – 300 milijuna ljudi u svijetu bolovalo od astme, a godišnje od nje umire 250 000 ljudi. Prevalencija i incidencija astme je posljednjih desetljeća u porastu kod djece i kod odraslih. Prevalencija astme u svijetu se trenutno kreće između 1-18%. Viša prevalencija se primjećuje u razvijenijim državama. Iako se smrtnost od astme u zadnjih nekoliko godina smanjila, još uvijek postoji. Smatra se da astma uzrokuje 1 od 250 smrti u svijetu. Prema zdravstvenim troškovima, astma je 5. u svijetu i ima veliko javnozdravstveno značenje. Prevalencija astme u Hrvatskoj se kreće između 5-8% u djece i školske mladeži, a pretpostavlja se da je prevalencija u općoj populaciji između 3-4%. Astma je odgovorna za oko 0,13% smrti godišnje u Hrvatskoj, a dobno standardizirana stopa smrtnosti iznosi 0,86/100.000 stanovnika. Astma se smatra globalnim problemom i „bremenom“ populacije. Istraživanje uzroka astme i provedba primarne i sekundarne prevencije su ključ strategije za smanjenje pobola i smrtnosti od astme.

Abstract (english)

Asthma is a chronic inflammatory disease of the airways. Clinical manifestations of the disease are a result of increased intensitiy of the inflammation. Asthma is a heterogenous disease. It is believed that asthma is caused by combination of genetic and environmental factors. Main pathogenetic features of asthma are inflammation of the airways and bronchial hyperreactivity. Signs and symptoms of asthma vary. Periods of complete absence of symptoms alternate with exacerbations of the disease. Many tests are being used in diagnosis of asthma, but none of them are sufficiently sensitive nor specific enough. Lung function tests have the most value in diagnosing and assesing the severity of asthma. Treatment of asthma requires a comprehensive plan that includes general measures, drug therapy and patient education. Corticosteroids are considered to be the most useful drugs in disease control, and short – acting beta2-agonists are most common medication used for the temporary relief of symptoms. Patients are treated according to GINA guidelines. Asthma is one of the most common chronic diseases in the world. As of 2011, 250–300 million people worldwide are affected by asthma, and approximately 250,000 people die per year from the disease. The prevalence and incidence of asthma in recent decades are increasing in both children and adults. The prevalence of asthma in the world is currently between 1-18%. Higher prevalence is observed in countries with higher economic standard. Although mortality from asthma has been reduced in recent years, it still exists. It is believed that asthma is the cause of 1/250 deaths in the world. Asthma is fifth in the world in health care costs and has a large significance in public health. The prevalence of asthma in Croatia ranges between 5-8% in children, and it is assumed that the prevalence in the general population ranges between 3-4%. Asthma is responsible for approximately 0.13% of all the deaths in Croatia, and the age-standardized death rate was 0.86/100,000. Asthma is considered a global problem and the "burden" to the population. Future research of the causes of asthma and implementation of primary and secondary prevention methods is the key strategy for reducing morbidity and mortality of asthma.

• Keywords: astma; epidemiologija; Hrvatska
• Keywords (english): asthma; epidemiology; Croatia
• Language: croatian
• URN:NBN: urn:nbn:hr:105:863310
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-04-01 12:06:23