| Abstract | Uvod: Povećanje učestalosti Diabetesa u trudnoći I makrosomne djece nosi veliki rizik za
razvitak bolesti povezane za pretilost kao metabolički sindrom I tip 2 dijabetesa.
Ciljevi: Cilj istraživanja je ispitati uzrok pojačanog fetalnog razvitka( > 90 centile ) kod trudnica
sa dobrom kontrollom gestacijskog diabetesa.
Pacijenti i Metode: 37 trudne žene sa GDM i 46 zdravih trudnoća kao kontrolna grupa I njihova
novorodenčad su sudjelovali u istraživanju. Uzorci krvi uzeti su od majke prije poroda i od
novorodenih u vrijeme poroda I testirana je koncentracije adiponektina, leptina , insulin , c
peptida, kolesterola, triglicerida, HDL i LDL kolesterol.
Nalazi: Majke sa diabetesom u trudnoći imaju značajno veći BMI ( prvotromjesečje ) od
kontrolne skupine ( 29,6 ± 6,0 vs. 23,3 ± 4,3 , P < 0,0001 ) , a koncentracija adiponektina su
značajno niže u Majke sa diabetesom u trudnoći u usporedbi sa zdravim kontrolnim ispitanicima
( 10.871,3 ± 5184,2 vs 13.418,9 ± 5148,6 , P = 0,021 ) .
U djece majki sa diabetesom koncentracije adiponektina ( 24.469,0 10.478,8 ± vs 45.359,6 ±
7.592 , P = 0.0017 ) su znatno niže kod LGA djece majki s dijabetesom u usporedbi sa LGA
djece zdrave kontrolne grupe ; I koncentracija inzulina je znacajno viša u AGA ( 11,3 ± 14,1
vs.4.3 ± 3,2 , P < 0,0001 ) i LGA ( 12,9 ± 6,4 vs 5,8 ± 2,9 , P = 0,035 ) djece majki s diabetesom
u usporedbi sa AGA i LGA djece zdrave kontrolne grupe.
Zakljucak: Nalazi ovog istraživanja opisuju metabolicke promjene koje okružuju plod kod
dobro kontroliranog diabetesa u trudnoći. Hiperinzulinemija I hypoadiponectinemia u
makrosomne dojenčadi su predisponirajući čimbenici koji mogu pridonijeti u razvoju bolesti
povezane za pretilosti kasnije u životu. |
| Abstract (croatian) | Introduction: Increasing incidence of GDM and LGA births predispose children for obesity
related diseases, metabolic syndrome and type 2 Diabetes.
Aims: The aim of the study was to investigate the cause of enhanced fetal growth (>90 centiles)in
well controlled gestational diabetic pregnancies.
Subjects and methods: 37 GDM mothers and 46 healthy control subjects and their newborns
participated in the cross sectional study. Blood samples were taken from mother before delivery
and from neonates at the time of delivery and tested for concentration of adiponectin, leptin,
insulin, c peptide, cholesterol, triglycerides, HDL and LDL cholesterol.
Results: Gestational diabetic mothers had significantly higher BMI (first trimester) than a control
group (29.6 ±6.0 vs. 23.3 ± 4.3, P<0.0001) and adiponectin concentration were significantly
lower in gestational diabetic mothers compared with healthy control subjects (10871.3 ± 5184.2
vs. 13418.9 ± 5148.6, P=0.021). In offspring of GDM concentration of adiponectin (24469.0 ±
10478.8 vs. 45359.6 ± 7592, P=0.0017) is significantly lower in LGA newborns of GDM
mothers compared with LGA newborns of healthy control; and concentration of Insulin is
significantly higher in AGA (11.3 ±14.1 vs.4.3 ±3.2, P<0.0001) and LGA (12.9 ±6.4 vs. 5.8 ±2.9,
P=0.035) newborn of GDM mothers compared with AGA and LGA newborns of healthy control.
Conclusions: The findings of this study describe an altered metabolic environment for the fetus
even in well controlled GDM mothers. Hyperinsulinemia and hypoadiponectinemia in
macrosomic infants are predisposing factors that can contribute in development of obesity
related disorder later in their life. |
