Utjecaj prekomjerne tjelesne mase, debljine i visceralne masti na spermiogram i hormonski status

doctoral thesis

• Title (english): Influence of overweight, obesity and visceral fat on spermiogram and hormonal status
• Author: Sonja Anić Jurica
• Mentor: Miro Kasum (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2018-07-04, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Uvod: Dosadašnja istraživanja o utjecaju prekomjerne tjelesne mase, debljine i visceralne masti na spermiogram i hormonski status muškaraca su proturječna.
Ciljevi: Istražiti utjecaj povećane tjelesne mase, debljine i visceralne masti na spermiogram i hormonski status.
Materijali i metode: Istraživanje je uključivalo 127 muškaraca kod kojih je analizirano sjeme; 66 u ispitivanoj skupini s patološkim nalazom sjemena i 61 u kontrolnoj skupini s urednim nalazom spermiograma. Uspoređena su različita antropometrijska mjerenja između skupina te njihov utjecaj na parametre sjemena i relevantni hormonski status. Rezultati: U ispitivanoj skupini nalazimo statistički značajno više vrijednosti FSH, LH te više vrijednosti E2 u odnosu na kontrolnu skupinu ispitanika, dok te razlike nisu utvrđene za testosteron i SHBG. Značajna je negativna korelacija vrijednosti FSH i LH i kvalitete sjemena. Značajno je viša koncentracija E2, a snižena vrijednost testosterona i SHBG kod muškaraca s povišenim ITM, omjerom opsega struka/bokova, udjelom i indeksom visceralne masti. Nije utvrđen negativan učinak debljine na kvalitetu sjemena. Vrijednosti FSH značajno su inverzno povezane s kvalitetom sjemena u cjelokupnoj populaciji uključenoj u istraživanje. Zaključak: Istraživanje pokazuje da debljina mijenja hormonski status muškaraca bez utjecaja na kvalitetu sjemena. Slijedom dokazane negativne korelacije s kvalitetom sjemena, koncentracija FSH može poslužiti kao indikator patološkog spermiograma u kliničkoj praksi, s graničnom vrijednošću ≥3,55 IU/L.

Abstract (english)

Introduction: Research results of overweight, obesity and visceral fat impact on spermiogram and hormonal status in men are contradictory. Aim: To investigate influence of overweight, obesity and visceral fat on spermiogram and hormonal status.
Matherials and methods: The study included 127 patients with semen analysis conducted; 66 in the group of interest with abnormal semen analysis and 61 in the control group with normal spermiogram results. Different antropometric measurements are compared between the groups and their impact on semen parameters and relevant hormonal status was investigated. Results: Group of interest had statisticaly significant higher levels of FSH, LH and higher levels of E2 compared to control while levels of total testosteron and SHBG were not significant. There were significant negative correlations of FSH and LH levels and semen quality. Increase of E2 and decreases of testosteron and SHBG in men with larger BMI, waist/hip ratio, visceral fat percantage and rating were significant. There was no negative impact of obesity on semen quality. FSH levels were significantly inversely correlated with semen quality in the whole study population. Conclusion: This study reveals that obesity alters hormonal status in men with no influence on semen quality. In the course of proven negative correlation with semen quality, FSH concentration may serve as an indicator of abnormal spermiogram in clinical practice, with border level ≥3,55 IU/L.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:837467
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 94 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 08:15:29