Određivanje volumena fetalnih pluća trodimenzionalnim ultrazvukom

doctoral thesis

• Title (english): Fetal lung volume determination using 3-D ultrasonography
• Author: Danka Mirić Tešanić; MBZ: 197571
• Mentor: Asim Kurjak (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2007-10-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Nedvojbeno je da mjerenje fetalnih pluća dvodimenzionalnom i trodimenzionalnom ultrazvučnom tehnikom može biti korisno u prenatalnoj dijagnostici plućne hipoplazije. Stoga je cilj ove studije bio, koristeći 3D ultrazvuk, izraditi nomograme za volumen fetalnih pluća. U ovu prospektivnu studiju uključeno je 300 fetusa gestacijske dobi od 18. do 34. tjedna. Mjerenja su obavljena na transverzalnom presjeku u multiplanarnom prikazu ručnim opcrtavanjem rubnih obrisa pluća - odvojeno desnoga i lijevoga plućnog krila, te posebno još i fetalnoga srca. Na osnovi tih mjerenja sastavljeni su nomograni volumena tih organa za gestacijsku dob. U našim smo rezultatima opazili porast volumena fetalnih pluća s rastom gestacijske dobi. Krivulja rasta volumena fetalnih pluća postaje strmija s 22. tjednom trudnoće i taj oblik zadržava do 34. tjedna. Uočena je i statistički značajna razlika u volumenu pluća između desnoga i lijevoga plućnoga krila. U studiju je također uključena skupina fetusa s određenim patološkim promjenama (displazija skeleta, hidrotoraks, višestruke fetalne malformacije) te su izmjereni i volumeni njihovih pluća koji su uspoređeni s upravo sačinjenim nomogramima. Volumeni pluća izmjereni u skupini malformiranih fetusa bili su ispod 5. centile za dob, osim u jednog fetusa s osteogenesis imperfecta. Volumetrijska mjerenja fetalnih pluća trodminezionalim ultrazvukom pogodna su za oktrivanje fetalne plućne hipoplazije već i prije 24. tjedna trudnoće.

Abstract (english)

The aim of the study was to establish fetal lung volume nomograms using 3D-ultrasonography. For this purpose a total of 300 fetuses were examined between 18 and 34 weeks of gestation. To determine fetal lung volume each lung was measured separately using transversal sectional plane in the multiplanar mode. Measurements were performed by area tracing around the fetal lung in cross-sectional planes. Calculated volume data were plotted against gestational age in order to obtain lung volume nomograms. Increased growth of the lung, thorax and heart volume was observed with advancing gestational age, starting with 22 weeks. Statistically significant difference was observed between right and left lung volume. In a group of 12 fetuses with suspected pulmonary hypoplasia calculated lung volumes were compared with established nomograms. Using a three dimensional ultrasound it is easy to perform fetal lung volume calculation, especially before the 30 weeks of gestation. Using this method pulmonary hypoplasia could be more precisely diagnosed. The encouraging results suggest that this method could be a method of choice for the early detection of pulmonary hypoplasia, even before 24 weeks of gestation.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:088771
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 105 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 08:48:10