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Scientific paper - Original scientific paper
Risks associated with prior oral anticoagulation use in hospitalized COVID-19 patients – A retrospective cohort study on 5392 patients from a tertiary centre
International Journal of Cardiology, 372 (2023); 144-149. https://doi.org/10.1016/j.ijcard.2022.11.051
Bistrović, Petra; Sabljic, Anica; Kovačević, Ivona; Čikara, Tomislav; Kereš, Tatjana; Lucijanić, Tomo; Mitrović, Joško; Delić-Brkljačić, Diana; Manola, Šime; Lucijanić, Marko

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Bistrović, P., Sabljic, A., Kovačević, I., Čikara, T., Kereš, T., Lucijanić, T. ... Lucijanić, M. (2023). Risks associated with prior oral anticoagulation use in hospitalized COVID-19 patients – A retrospective cohort study on 5392 patients from a tertiary centre. International Journal of Cardiology, 372., 144-149. doi: 10.1016/j.ijcard.2022.11.051

Bistrović, Petra, et al. "Risks associated with prior oral anticoagulation use in hospitalized COVID-19 patients – A retrospective cohort study on 5392 patients from a tertiary centre." International Journal of Cardiology, vol. 372, 2023, pp. 144-149. https://doi.org/10.1016/j.ijcard.2022.11.051

Bistrović, Petra, Anica Sabljic, Ivona Kovačević, Tomislav Čikara, Tatjana Kereš, Tomo Lucijanić, Joško Mitrović, Diana Delić Brkljačić, Šime Manola and Marko Lucijanić. "Risks associated with prior oral anticoagulation use in hospitalized COVID-19 patients – A retrospective cohort study on 5392 patients from a tertiary centre." International Journal of Cardiology 372 (2023): 144-149. https://doi.org/10.1016/j.ijcard.2022.11.051

Bistrović, P., et al. (2023) 'Risks associated with prior oral anticoagulation use in hospitalized COVID-19 patients – A retrospective cohort study on 5392 patients from a tertiary centre', International Journal of Cardiology, 372, pp. 144-149. doi: 10.1016/j.ijcard.2022.11.051

Bistrović P, Sabljic A, Kovačević I, Čikara T, Kereš T, Lucijanić T, and sur.. Risks associated with prior oral anticoagulation use in hospitalized COVID-19 patients – A retrospective cohort study on 5392 patients from a tertiary centre. International Journal of Cardiology [Internet]. 2023 February 01 [cited 2024 April 10];372:144-149. doi: 10.1016/j.ijcard.2022.11.051

P. Bistrović, et al., "Risks associated with prior oral anticoagulation use in hospitalized COVID-19 patients – A retrospective cohort study on 5392 patients from a tertiary centre", International Journal of Cardiology, vol. 372, pp. 144-149, February 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:310444. [Accessed: 10 April 2024]

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Metadata
Title (english)Risks associated with prior oral anticoagulation use in hospitalized COVID-19 patients – A retrospective cohort study on 5392 patients from a tertiary centre
AuthorPetra Bistrović
AuthorAnica Sabljic
AuthorIvona Kovačević
AuthorTomislav Čikara
AuthorTatjana Kereš
AuthorTomo Lucijanić
AuthorJoško Mitrović
AuthorDiana Delić-Brkljačić
AuthorŠime Manola
AuthorMarko Lucijanić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Introduction: There are conflicting data on prior oral-anticoagulant (OAC) use and outcomes of hospitalized COVID-19 patients. Due to uncertainties regarding associated risks with the prior OAC use, we have investigated this issue in a large cohort of hospitalized COVID-19 patients from our institution. Methods: We have retrospectively evaluated a total of 5392 consecutive COVID-19 patients hospitalized in our tertiary center institution in period 3/2020 to 6/2021. Majority of patients received low-molecular-weight-heparin thromboprophylaxis and corticosteroids during hospitalization. Patients' characteristics and clinical outcomes were documented as a part of a hospital registry project and were evaluated according to the prior non-OAC, warfarin and direct oral anticoagulants (DOAC) use. Results: Median age was 72 years, median Charlson comorbidity index (CCI) was 4 points. There were 56.2% male patients. Majority of patients had severe (70.5%) or critical (15.8%) COVID-19 on admission. A total of 84.8% patients did not receive prior OAC, 9% were previously anticoagulated with warfarin and 6.2% were previously anticoagulated with DOACs. In the multivariate regression analyses, prior warfarin use was associated increased in-hospital mortality (OR 1.24, P = 0.048) independently of older age (OR 2.12, P < 0.001), male sex (OR 1.27, P < 0.001), higher CCI (OR 1.26, P < 0.001) and severe or critical COVID-19 on admission (OR 22.66, P < 0.001). Prior DOAC use was associated with higher occurrence of major bleeding (OR 1.72, P = 0.045) independently of higher CCI (OR 1.08, P = 0.017). Conclusion: Prior OAC use could be associated with worse clinical outcomes during COVID-19 hospitalization. These phenomena might be OAC type specific and persist after multivariate adjustments.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Cardiology
Numberingvol. 372, pp. 144-149
p-ISSN0167-5273
DOIhttps://doi.org/10.1016/j.ijcard.2022.11.051
URN:NBNurn:nbn:hr:105:310444
Publication2023-02-01
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0167527322017387
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-18 10:31:32