Mechanistic View on the Effects of SGLT2 Inhibitors on Lipid Metabolism in Diabetic Milieu

Scientific paper - Review paper

• Author: Habib Yaribeygi
• Author: Mina Maleki
• Author: Željko Reiner
• Author: Tannaz Jamialahmadi
• Author: Amirhossein Sahebkar
• Author's institution: University of Zagreb; School of Medicine; (Department of Medical Microbiology and Parasitology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Medical Microbiology

Abstract (english)

Chronic hyperglycemia induces pathophysiologic pathways with negative effects on the metabolism of most substrates as well as lipids and lipoproteins, and thereby induces dyslipidemia. Thus, the diabetic milieu is commonly accompanied by different levels of atherogenic dyslipidemia, which is per se a major risk factor for subsequent complications such as atherosclerosis, coronary heart disease, acute myocardial infarction, ischemic stroke, and nephropathy. Therefore, readjusting lipid metabolism in the diabetic milieu is a major goal for preventing dyslipidemia-induced complications. Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a class of relatively newly introduced antidiabetes drugs (including empagliflozin, canagliflozin, dapagliflozin, etc.) with potent hypoglycemic effects and can reduce blood glucose by inducing glycosuria. However, recent evidence suggests that they could also provide extra-glycemic benefits in lipid metabolism. It seems that they can increase fat burning and lipolysis, normalizing the lipid metabolism and preventing or improving dyslipidemia. Nevertheless, the exact mechanisms involved in this process are not well-understood. In this review, we tried to explain how these drugs could regulate lipid homeostasis and we presented the possible involved cellular pathways supported by clinical evidence.

• Keywords (english): cholesterol; diabetes mellitus; lipids; lipogenesis; lipolysis; oxidative stress; sodium-glucose cotransporter-2 inhibitors; β-oxidation
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Journal of Clinical Medicine
• Numbering: vol. 11, no. 21, 6544
• e-ISSN: 2077-0383
• DOI: https://doi.org/10.3390/jcm11216544
• URN:NBN: urn:nbn:hr:105:843634
• Publication: 2022-11-04
• Document URL: https://www.mdpi.com/2077-0383/11/21/6544
• Type of resource: Text
• Access conditions: Open access
• Created on: 2023-07-13 07:16:38