prikaz prve stranice dokumenta Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients
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Scientific paper - Original scientific paper
Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients
Biomolecules, 12 (2022), 10; 1488. https://doi.org/10.3390/biom12101488
Žarković, Neven; Orehovec, Biserka; Baršić, Bruno; Tarle, Marko; Kmet, Marta; Lukšić, Ivica; Tatzber, Franz; Wonisch, Willibald; Skrzydlewska, Elżbieta; Łuczaj, Wojciech

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Žarković, N., Orehovec, B., Baršić, B., Tarle, M., Kmet, M., Lukšić, I. ... Łuczaj, W. (2022). Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients. Biomolecules, 12. (10). doi: 10.3390/biom12101488

Žarković, Neven, et al. "Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients." Biomolecules, vol. 12, no. 10, 2022. https://doi.org/10.3390/biom12101488

Žarković, Neven, Biserka Orehovec, Bruno Baršić, Marko Tarle, Marta Kmet, Ivica Lukšić, Franz Tatzber, Willibald Wonisch, Elżbieta Skrzydlewska and Wojciech Łuczaj. "Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients." Biomolecules 12, no. 10 (2022). https://doi.org/10.3390/biom12101488

Žarković, N., et al. (2022) 'Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients', Biomolecules, 12(10). doi: 10.3390/biom12101488

Žarković N, Orehovec B, Baršić B, Tarle M, Kmet M, Lukšić I, and sur.. Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients. Biomolecules [Internet]. 2022 October 15 [cited 2024 December 20];12(10). doi: 10.3390/biom12101488

N. Žarković, et al., "Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients", Biomolecules, vol. 12, no. 10, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:350109. [Accessed: 20 December 2024]

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Metadata
Title (english)Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients
AuthorNeven Žarković
AuthorBiserka Orehovec
AuthorBruno Baršić
AuthorMarko Tarle
AuthorMarta Kmet
AuthorIvica Lukšić
AuthorFranz Tatzber
AuthorWillibald Wonisch
AuthorElżbieta Skrzydlewska
AuthorWojciech Łuczaj
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Maxillofacial Surgery and Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Thorough understanding of metabolic changes, including lipidome alteration, associated with the development of COVID-19 appears to be crucial, as new types of coronaviruses are still reported. In this study, we analyzed the differences in the plasma phospholipid profiles of the deceased COVID-19 patients, those who recovered and healthy people. Due to identified abnormalities in plasma phospholipid profiles, deceased patients were further divided into two subgroups (D1 and D2). Increased levels of phosphatidylethanolamines (PE), phosphatidylcholines (PC) and phosphatidylserines (PS) were found in the plasma of recovered patients and the majority of deceased patients (first subgroup D1) compared to the control group. However, abundances of all relevant PE, PC and PS species decreased dramatically in the plasma of the second subgroup (D2) of five deceased patients. These patients also had significantly decreased plasma COX-2 activity when compared to the control, in contrast to unchanged and increased COX-2 activity in the plasma of the other deceased patients and recovered patients, respectively. Moreover, these five deceased patients were characterized by abnormally low CRP levels and tremendous increase in LDH levels, which may be the result of other pathophysiological disorders, including disorders of the immune system, liver damage and haemolytic anemia. In addition, an observed trend to decrease the autoantibodies against oxidative modifications of low-density lipoprotein (oLAb) titer in all, especially in deceased patients, indicate systemic oxidative stress and altered immune system that may have prognostic value in COVID-19.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 12, no. 10, 1488
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom12101488
URN:NBNurn:nbn:hr:105:350109
Publication2022-10-15
Document URLhttps://www.mdpi.com/2218-273X/12/10/1488
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-08-21 08:10:11