Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients

Scientific paper - Original scientific paper

• Author: Neven Žarković
• Author: Biserka Orehovec
• Author: Bruno Baršić
• Author: Marko Tarle
• Author: Marta Kmet
• Author: Ivica Lukšić
• Author: Franz Tatzber
• Author: Willibald Wonisch
• Author: Elżbieta Skrzydlewska
• Author: Wojciech Łuczaj
• Author's institution: University of Zagreb; School of Medicine; (Department of Maxillofacial Surgery and Dentistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery

Abstract (english)

Thorough understanding of metabolic changes, including lipidome alteration, associated with the development of COVID-19 appears to be crucial, as new types of coronaviruses are still reported. In this study, we analyzed the differences in the plasma phospholipid profiles of the deceased COVID-19 patients, those who recovered and healthy people. Due to identified abnormalities in plasma phospholipid profiles, deceased patients were further divided into two subgroups (D1 and D2). Increased levels... More of phosphatidylethanolamines (PE), phosphatidylcholines (PC) and phosphatidylserines (PS) were found in the plasma of recovered patients and the majority of deceased patients (first subgroup D1) compared to the control group. However, abundances of all relevant PE, PC and PS species decreased dramatically in the plasma of the second subgroup (D2) of five deceased patients. These patients also had significantly decreased plasma COX-2 activity when compared to the control, in contrast to unchanged and increased COX-2 activity in the plasma of the other deceased patients and recovered patients, respectively. Moreover, these five deceased patients were characterized by abnormally low CRP levels and tremendous increase in LDH levels, which may be the result of other pathophysiological disorders, including disorders of the immune system, liver damage and haemolytic anemia. In addition, an observed trend to decrease the autoantibodies against oxidative modifications of low-density lipoprotein (oLAb) titer in all, especially in deceased patients, indicate systemic oxidative stress and altered immune system that may have prognostic value in COVID-19. Less

• Keywords (english): Autoantibodies; COVID-19; Cyclooxygenase 2; Humans; Lipidomics; Lipoproteins, LDL; Phosphatidylcholines; Phosphatidylethanolamines / metabolism; Phosphatidylserines / metabolism; Phospholipids / metabolism
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Biomolecules
• Numbering: vol. 12, no. 10, 1488
• e-ISSN: 2218-273X
• DOI: https://doi.org/10.3390/biom12101488
• URN:NBN: urn:nbn:hr:105:350109
• Publication: 2022-10-15
• Document URL: https://www.mdpi.com/2218-273X/12/10/1488
• Type of resource: Text
• Access conditions: Open access
• Created on: 2023-08-21 08:10:11