Causative agents of bloodstream infections in two Croatian hospitals and their resistance mechanisms

Scientific paper - Original scientific paper

• Author: Branka Bedenić
• Author: Saša Likić
• Author: Marta Žižek
• Author: Vesna Bratić
• Author: Valentino D'Onofrio
• Author: Gordana Cavrić
• Author: Gordana Pavliša
• Author: Marijo Vodanović
• Author: Inge Gyssens
• Author: Ivan Barišić
• Author's institution: University of Zagreb; School of Medicine; (Department of Medical Microbiology and Parasitology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Medical Microbiology

Abstract (english)

Blood samples were collected alongside with routine blood cultures (BC) from patients with suspected sepsis, to evaluate the prevalence of different causative agents in patients with bacteraemia. Among 667 blood samples, there were 122 positive BC (18%). Haemoglobin content, platelet number, and systolic blood pressure values were significantly lower in patients with positive BC, whereas serum lactate levels, CRP, creatinine and urea content were significantly higher in patients with positive BC. The rate of multidrug (MDR) or extensively drug resistant (XDR) bacteria was 24% (n = 29): Klebsiella pneumoniae (9), Pseudomonas aeruginosa (9), Acinetobacter baumannii (4), Escherichia coli (1), vancomycin resistant Enterococcus spp (VRE) (3), and methicillin-resistant Staphylococcus aureus MRSA (3). The dominant resistance mechanisms were the production of extended-spectrum β-lactamases, OXA-48 carbapenemase, and colistin resistance in K. pneumoniae, VIM metallo-β-lactamases in P. aeruginosa and OXA-23-like oxacillinases in A. baumannii. The study revealed high rate of MDR strains among positive BCs in Zagreb, Croatia.

• Keywords (english): Acinetobacter baumannii; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bacteremia / drug therapy; Bacteremia / epidemiology; Bacteremia / microbiology; Croatia / epidemiology; Drug Resistance, Multiple, Bacterial; Hospitals; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; beta-Lactamases
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Journal of Chemotherapy
• Numbering: vol. 35, no. 4, pp. 281-291
• p-ISSN: 1120-009X
• e-ISSN: 1973-9478
• DOI: https://doi.org/10.1080/1120009X.2022.2104294
• URN:NBN: urn:nbn:hr:105:463505
• Publication: 2022-07
• Document URL: https://www.tandfonline.com/doi/full/10.1080/1120009X.2022.2104294
• Type of resource: Text
• Access conditions: Open access; Embargo expiration date: 2024-08-01
• Created on: 2023-08-28 08:18:58