Risk assessment, therapy and prevention of early-onset neonatal sepsis

master's thesis

• Title (croatian): Rizični čimbenici, prevencija i liječenje rane novorođenačke sepse
• Author: Matthias Stefan Kolonko
• Mentor: Mirta Starčević (mentor)
• Committee member: Mirta Starčević (predsjednik povjerenstva)
• Committee member: Boris Filipović-Grčić (član povjerenstva)
• Committee member: Marija Jelušić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract

The heterogeneous presentation of early-onset sepsis (EOS) makes the early diagnosis and management of EOS in newborns a challenging task for neonatology healthcare teams. On one hand, early unspecific signs of EOS can be easily overlooked and on the other hand, unwarranted empiric treatment with antibiotics can have long-term negative health consequences for infants. Therefore, the management of neonates with suspected or culture-positive proven EOS requires standardized and evidence-based diagnostic and therapeutic approaches. The guidelines presented in this review include the most widely used and extensively researched recommendations on neonatal EOS from highly science-oriented national healthcare organizations, such as the Centers for Disease Control and Prevention (CDC), the American Academy of Pediatrics (AAP) in the United States, and the National Institute for Health and Care Excellence (NICE) in the UK. This review aims to compare and discuss the important role of up-to-date risk assessment tools for early-onset neonatal sepsis, such as the Kaiser Permanente Neonatal Sepsis Calculator (SRC), the NICE guidelines for neonatal infection, as well as modern neonatal sepsis treatment and prevention strategies.

Abstract (croatian)

Raznolikost kliničke prezentacije rane neonatalne sepse čini dijagnozu i liječenje izazovnim zadatkom za neonatološke zdravstvene timove. S jedne strane, rani nespecifični znakovi neonatalne sepse mogu se lako previdjeti, a s druge strane, neopravdano empirijsko liječenje antibioticima može imati dugoročne negativne zdravstvene posljedice za novorođenčad. Iz tog razloga, liječenje novorođenčadi sa sumnjom na ranu novorođenačku sepsu ili dokazanom infekcijom zahtijeva standardizirane dijagnostičke i terapijske postupke utemeljene na znanstvenih dokazima. Smjernice predstavljene u ovom diplomskom radu najčešće su korištene i opsežno istražene preporuke o pristupu neonatalnoj sepsi od visoko znanstveno orjentiranih nacionalnih zdravstvenih organizacija, kao što su Centers for Disease Control and Prevention (CDC) i American Academy of Pediatrics (AAP) u Sjedinjenim Američkim Državama, te National Institute for Health and Care Excellence (NICE) u Velikoj Britaniji. Ovaj diplomski rad ima za cilj usporediti i raspraviti važnost uloge suvremenih alata za procjenu rizika rane novorođenačke sepse, kao što su Kaiser Permanente kalkulator za novorođenačku sepsu ili NICE smjernice za neonatalnu infekciju, te prikazati moderne strategije prevencije i liječenja.

• Keywords: Early-Onset Sepsis; Risk Assessment; Sepsis Risk Calculator; Antibiotic Treatment; Prevention
• Keywords (croatian): Rana novorođenačka sepsa; Rizični čimbenici; Kaiser Permanente Sepsis Risk Kalkulator; prevencija; liječenje
• Language: english
• URN:NBN: urn:nbn:hr:105:111326
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-09-01 11:25:08