The role of limosilactobacillus reuteri strains on human health

master's thesis

• Title (croatian): Uloga sojeva bakterije limosilactobacillus reuteri na ljudsko zdravlje
• Author: Adam Bošnjak
• Mentor: Mihaela Perić (mentor)
• Committee member: Mihaela Perić (predsjednik povjerenstva)
• Committee member: Fran Borovečki (član povjerenstva)
• Committee member: Nino Sinčić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Medical Microbiology

Abstract

In recent years the human gastrointestinal microbiota has proven to play a critical role in host health and disease. The majority of human microbiota resides in the large intestine and is composed of a diverse array of microorganisms, including bacteria, fungi, and archaea. Among these, Limosilactobacillus reuteri (formerly known as Lactobacillus reuteri), a gram-positive, heterofermentative lactic acid bacterium has gained attention as a probiotic due to its potential health benefits. Several strains of L. reuteri have been identified, each with its unique set of functional genes contributing to its probiotic effects. The beneficial properties include gastrointestinal microbiota modulation, pathogen colonization resistance, cobalamin synthesis, as well as positive endocrine, musculoskeletal, integumentary effects, anti-inflammatory, and neurodevelopmental effects.

Many chronic diseases have been associated with states of microbiota imbalance called dysbiosis. In contrast to the conventional pharmaceutical management of chronic diseases, probiotics such as L. reuteri could serve as important treatment options to rehabilitate perturbed microbial ecosystems and its functionally active metabolites, thus improving the safety and efficacy of current clinical practices. With more data gathered, L. reuteri could become a valuable tool for treating chronic conditions and restoring human health.

Abstract (croatian)

Posljednjih godina istraživanja su pokazala da mikrobiota probavnog trakta igra ključnu ulogu u zdravlju i bolesti ljudi. Većina ljudske mikrobiote nalazi se u debelom crijevu i sastoji se od raznolikog niza mikroorganizama, uključujući bakterije, gljivice, i arheje. Među njima se ističe gram-pozitivna, heterofermentativna bakterija mliječne kiseline Limosilactobacilllus reuteri (ranije poznata kao Lactobacillus reuteri) koja je privukla pozornost kao probiotik zbog svojih potencijalnih zdravstvenih koristi. Identificirano je nekoliko sojeva L. reuteri, koji svaki sa svojim jedinstvenim skupom funkcionalnih gena pridonose specifičnim probiotičkim učincima. Tu spadaju modulacija gastrointestinalne mikrobiote, otpornost na kolonizaciju patogena, sinteza kobalamina te pozitivni učinci na endokrini, mišićno-koštani, pokrovni i imuni sustav te na neurorazvoj.

Mnoge kronične bolesti povezuju se sa stanjima neravnoteže mikrobiote koja se nazivaju disbiozom. Za razliku od konvencionalnog farmaceutskog liječenja kroničnih bolesti, probiotici poput L. reuteri mogli bi poslužiti kao važne terapijske opcije u oporavku narušenih mikrobnih ekosustava i njegovih funkcionalno aktivnih metabolita te tako unaprijediti sigurnost i učinkovitost trenutnih kliničkih praksi. S više prikupljenih podataka, L. reuteri bi mogao postati vrijedan alat za liječenje kroničnih stanja kao i za unapređenje ljudskog zdravlja.

• Keywords: Limosilactobacillus reuteri; probiotic; gastrointestinal microbiota; dysbiosis; treatment
• Keywords (croatian): Limosilactobacillus reuteri; probiotik; crijevna mikrobiota; disbioza; liječenje
• Language: english
• URN:NBN: urn:nbn:hr:105:228147
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-09-04 11:14:27