Title Multisustavne manifestacije kronične opstruktivne plućne bolesti Title (english) Multisystemic manifestations of chronic obstructive pulmonary disease Author Antun Botica Mentor Gordana Pavliša (mentor)Committee member Andrea Vukić Dugac (predsjednik povjerenstva)Committee member Marko Jakopović (član povjerenstva)Committee member Gordana Pavliša (član povjerenstva)Granter University of Zagreb Defense date and country 2023-07-13, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Kronična opstruktivna plućna bolest (KOPB) heterogena je bolest karakterizirana kroničnim respiratornim simptomima, abnormalnošću dišnih putova i/ili alveola te trajnom, često progresivnom opstrukcijom protoku zraka s periodičkim akutnim epizodama pogoršanja. Zbog visoke prevalencije i rastuće incidencije, ona danas predstavlja jedan od glavnih javnozdravstvenih problema. Patofiziološki se radi o kroničnoj upali dišnih puteva i plućnog parenhima uz nisku razinu kronične sustavne upale. KOPB
... More nije bolest koja zahvaća isključivo pluća, već je često udružena s drugim bolestima i stanjima koja imaju utjecaj na kvalitetu života bolesnika, tijek osnovne bolesti, kliničku sliku, prognozu i preživljenje. Prisutnost komorbiditeta povečava učestalost hospitalizacija, produžuje oporavak, a time i duljinu hospitalizacije. Najčešći komorbiditeti koji se povezuju s KOPB-om su kardiovaskularne bolesti, bronhiektazije, karcinom pluća, anemija, metabolički sindrom, dijabetes tip 2, osteoporoza, atrofija skeletnog mišićnog sustava, pothranjenost, pretilost, opstruktivna apneja u spavanju, gastroezofagealni refluks, depresija i anksiozni poremećaji. Povezanost ovih bolesti s KOPB-om objašnjava se postojanjem istih ili sličnih zajedničkih čimbenika rizika, kroničnom sustavnom upalom, oksidativnim stresom, kroničnom hipoksijom. Uz to, neki komorbiditeti mogu biti uzrokovani ili pogoršani terapijskim intervencijama, posebno uporabom kortikosteroida. Ukupni dijagnostički i terapijski pristup bolesniku s KOPB-om treba uključivati identifikaciju, dijagnostiku i liječenje svih sustavnih manifestacija bolesti. Procjenjuje se da su komorbiditeti odgovorni za približno 60% smrtnosti u KOPB-u, što dodatno naglašava važnost njihove adekvatne dijagnoze i zbrinjavanja. U većini slučajeva, komorbiditeti ne utječu na metode liječenja te se terapija provodi po standardnim smjernicama i protokolima. U nekim je slučajevima, ipak potrebno prilagoditi pojedine komponente i poduzeti određene mjere opreza da ne bi došlo do dodatnih komplikacija. Less Abstract (english) Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by chronic respiratory symptoms, abnormalities in the airways and/or alveoli, and persistent, often progressive airflow obstruction with periodic acute exacerbations. Due to its high prevalence and increasing incidence, it is now one of the major public health problems. Pathophysiologically, it involves chronic inflammation of the airways and lung parenchyma with a low level of chronic systemic
... More inflammation. COPD is not solely a lung disease; it is often associated with other diseases and conditions that impact the quality of life of patients, the course of the underlying disease, clinical presentation, prognosis, and survival. The presence of comorbidities increases the frequency of hospitalizations, prolongs recovery, and therefore, the length of hospital stay. The most common comorbidities associated with COPD are cardiovascular diseases, bronchiectasis, lung cancer, anemia, metabolic syndrome, type 2 diabetes, osteoporosis, skeletal muscle atrophy, malnutrition, obesity, obstructive sleep apnea, gastroesophageal reflux, depression, and anxiety disorders. The association of these diseases with COPD can be explained by the presence of shared or similar risk factors, chronic systemic inflammation, oxidative stress, and chronic hypoxia. In addition, some comorbidities may be caused or worsened by therapeutic interventions, especially the use of corticosteroids. The overall diagnostic and therapeutic approach to patients with COPD should include the identification, diagnosis, and treatment of all systemic manifestations of the disease. Comorbidities are estimated to be responsible for approximately 60% of mortality in COPD, further emphasizing the importance of their adequate diagnosis and management. In most cases, comorbidities do not affect the treatment methods, and therapy is carried out according to standard guidelines and protocols. However, in some cases, it may be necessary to adjust certain components and take precautions to avoid additional complications. Less Keywords
kronična opstruktivna plućna bolest
komorbiditeti
faktori rizika
kronična sustavna upala
oksidativni stres
hipoksija
Keywords (english)
chronic obstructive pulmonary disease
comorbidities
risk factors
chronic systemic inflammation
oxidative stress
hypoxia
Language croatian URN:NBN urn:nbn:hr:105:490495 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2023-10-23 11:10:34
