Indikacije, protokoli i zamke magnetske rezonancije cijelog tijela

master's thesis

• Title (english): Indications, protocols and pitfalls of whole-body magnetic resonance imaging
• Author: Marina Dasović
• Mentor: Gordana Ivanac (mentor)
• Committee member: Boris Brkljačić (predsjednik povjerenstva)
• Committee member: Milan Radoš (član povjerenstva)
• Committee member: Gordana Ivanac (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Radiology); Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiology

Abstract

Magnetska rezonancija cijelog tijela (WB-MRI) neinvazivna je slikovno dijagnostička metoda koja u jednom snimanju pruža podatke o brojnim organima i organskim sustavima. Za razliku od drugih slikovnih testova, kao što su konvencionalne rendgenske i CT snimke, MRI, pa tako ni WB-MRI, ne koristi ionizirajuće zračenje, što ju čini sigurnijom opcijom za dugoročno praćenje bolesti. WB-MRI predmet je brojnih medicinskih istraživanja, ali u praksi već postoje smjernice za njezino korištenje, primjerice u pacijenata oboljelih od multiplog mijeloma, uznapredovalog karcinoma prostate, metastatskog melanoma, a koristi se i u praćenju pacijenata sa sindormima s predispozicijom za razvoj raka te u reumatologiji. Postoje studije o potencijalnoj koristi WB-MRI u dijagnostici i praćenju nekih drugih malignih bolesti kao što su karcinom dojke, kolorektalni karcinom, karcinom jajnika i limfom. Upotreba WB-MRI u screeningu za rak u asimptomatskoj općoj populaciji još uvijek je predmet diskusije te zasad ne postoje indikacije za njeno korištenje u ovoj populaciji. Postojeće smjernice definiraju jasne protokole snimanja WB-MRI, koja se mogu provesti unutar 30 do 45 minuta. Važno je naglasiti da postoje i određena ograničenja i zamke u snimanju i interpretaciji nalaza WB-MRI. Ograničenje u prikazivanju lezija manjih od 5 mm te mogućnost davanja lažno pozitivnih i lažno negativnih nalaza samo su neke od zamki. Potrebno je provesti dodatna istraživanja kako bi se jasno i nedvosmisleno definirale indikacije za korištenje ove slikovne metode.

Abstract (english)

Whole-body magnetic resonance imaging (WB-MRI) is a non-invasive imaging diagnostic method that provides data on numerous organs and organ systems in a single imaging. Unlike other imaging tests, such as conventional radiograph and CT scans, MRI, including WB-MRI, does not use ionizing radiation, making it a safer option for long-term disease monitoring. WB-MRI is the subject of numerous medical studies, but certain guidelines for its use already do exist, for example in patients suffering from multiple myeloma, advanced prostate cancer, metastatic melanoma; it is also used in the monitoring of patients with cancer predisposition syndromes and in rheumatology. There are studies on the potential benefits of WB-MRI in the process of diagnosis and follow-up in other malignancies such as breast cancer, colorectal cancer, ovarian cancer and lymphoma. The use of WB-MRI in screening for cancer in the asymptomatic general population is still a topic of discussion and so far there are no indications for its use in this population. Existing guidelines define straightforward WB-MRI imaging protocols, which can be carried out within 30 to 45 minutes. It is important to emphasize that there are also certain limitations and pitfalls in the recording and interpretation of WB-MRI findings. The limitation in the presentation of lesions of less than 5 mm and the possibility of giving false positives and false negatives are just some of the pitfalls. Additional research should be carried out in order to clearly and unambiguously define the indications for the use of this imaging method.

• Keywords: magnetska rezonancija; onkologija; protokoli oslikavanja
• Keywords (english): magnetic resonance imaging; oncology; imaging protocols
• Language: croatian
• URN:NBN: urn:nbn:hr:105:132881
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-24 08:52:30