Kožne manifestacije endokrinih poremećaja

master's thesis

• Title (english): Skin manifestations of endocrine disorders
• Author: Iva Duliba
• Mentor: Romana Čeović (mentor)
• Committee member: Branka Marinović (predsjednik povjerenstva)
• Committee member: Zrinka Bukvić Mokos (član povjerenstva)
• Committee member: Romana Čeović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Dermatology); Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract

Hormoni sudjeluju u regulaciji fizioloških procesa u svim organskim sustavima, uključujući kožu. Endokrini sustav i koža u interakciji su putem kompleksnih mehanizama te endokrini poremećaji, zbog manjka ili viška određenih hormona, dovode do promjena u morfologiji i funkciji kože. Kožne manifestacije mogu poslužiti kao marker endokrinih poremećaja, a ponekad mogu biti i prva manifestacija endokrinog poremećaja. Iako pojedine kožne manifestacije mogu biti patognomonične za podležeću endokrinopatiju, većina je nespecifična i zahtijeva pažljivu evaluaciju. Neke se kožne manifestacije mogu prepoznati kliničkim pregledom, dok je za druge potrebna biopsija i patohistološka analiza. Važno je odabrati ispravne dijagnostičke metode radi otkrivanja podležeće endokrinopatije u svrhu zaobilaženja simptomatskog liječenja kožnih lezija i propisivanja primjerenog liječenja endokrinog poremećaja. Šećerna bolest, čija je incidencija u stalnom porastu, dovodi do brojnih komorbiditeta ako se ne liječi na vrijeme. Ako se poremećaji štitnjače ne dijagnosticiraju na vrijeme mogu imati značajan učinak na organizam zbog njihove uloge u regulaciji srčane i gastrointestinalne funkcije, razvoju i funkciji mozga, fizičkom razvoju i staničnom metabolizmu. Cushingov je sindrom povezan sa smanjenom kvalitetom života i povišenom smrtnosti zbog prisutnih komorbiditeta poput metaboličkog sindroma i hipertenzije koji značajno povisuju kardiovaskularni rizik. Najteža je klinička manifestacija Addisonove bolesti adrenalna kriza. Sindrom policističnih jajnika povezuje se s inzulinskom rezistencijom, intolerancijom glukoze i promjenama u metabolizmu lipida, a navedeno predstavlja faktore rizika za kardiovaskularnu bolest. Ovaj rad prikazuje navedene endokrinopatije i s njima povezane kožne manifestacije u svrhu što ranijeg otkrivanja endokrinih poremećaja kako bi se spriječile njihove komplikacije. Također su opisane dijagnostičke metode i terapija kožnih lezija i endokrinih poremećaja.

Abstract (english)

Hormones regulate physiological processes in every organ system, including the skin. The endocrine system and the skin interact through complex mechanisms, and endocrine disorders, due to the lack or excess of certain hormones, lead to changes in the morphology and function of the skin. Skin manifestations can serve as markers of endocrine disorders, sometimes being the first manifestation of an endocrine disorder. Although some skin manifestations may be pathognomonic of an underlying endocrinopathy, most are nonspecific and require careful evaluation. Some skin manifestations can be recognized on physical examination, while others require biopsy and pathohistological analysis. It is important to choose the correct diagnostic methods for detecting the underlying endocrinopathy in order to bypass the symptomatic treatment of skin lesions and to prescribe the appropriate treatment of the endocrine disorder. Diabetes mellitus, whose incidence is constantly increasing, leads to numerous comorbidities if not treated on time. If thyroid disorders are not diagnosed in time, they can have a significant effect on the body due to their role in the regulation of cardiac and gastrointestinal function, development and function of the brain, physical development, and cellular metabolism. Cushing's syndrome is associated with reduced quality of life and increased mortality due to its attributed comorbidities such as metabolic syndrome and hypertension, which significantly increase cardiovascular risk. Adrenal crisis is the most severe clinical manifestation of Addison's disease. Polycystic ovary syndrome is associated with insulin resistance, glucose intolerance and changes in lipid metabolism, all of which are risk factors for cardiovascular disease. This paper is an overview of the mentioned endocrinopathies and their attributed skin manifestations, with the purpose to detect endocrine disorders as early as possible in order to prevent their complications. Diagnostic methods and therapy of skin lesions and endocrine disorders are described as well.

• Keywords: endokrini poremećaji; kožne promjene; dermatovenerologija
• Keywords (english): endocrine disorders; skin changes; dermatovenerology
• Language: croatian
• URN:NBN: urn:nbn:hr:105:678598
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-24 09:34:59