Učestalost komponenata metaboličkog sindroma i masne jetre u bolesnika s teškom bakterijskom infekcijom

master's thesis

• Title (english): Frequency of metabolic syndrome components and fatty liver in patients with severe bacterial infection
• Author: Sanja Krüger
• Mentor: Neven Papić (mentor)
• Committee member: Adriana Vince (predsjednik povjerenstva)
• Committee member: Goran Tešović (član povjerenstva)
• Committee member: Neven Papić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Infectious Diseases); Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Infectology

Abstract

Metabolički sindrom i masna jetra česti su metabolički poremećaji koji nose značajan kardiovaskularni rizik te rizik za kroničnu jetrenu bolest. Ta dva entiteta isprepletena su u mreži patofizioloških mehanizama koji dovode do modulacije imunološkog odgovora, što bi mogla biti podloga za povećani rizik od infekcija. Cilj ovog rada bio je istražiti prevalenciju komponenata metaboličkog sindroma i masne jetre u hospitaliziranih bolesnika sa teškim bakterijskim infekcijama. Radi se o presječnom istraživanju na 319 ispitanika hospitaliziranih na Klinici za infektivne bolesti “Dr. Fran Mihaljević” u razdoblju od siječnja do prosinca 2022. godine. Osim bilježenja učestalosti navedenih stanja, ispitanici su grupirani prema dobi, spolu, kliničkom sindromu, stupnju steatoze i fibroze. Izračunate su ukupne prevalencije te prevalencije po kliničkim sinromima za pojedine komponente metaboličkog sindroma i NAFLD. Ispitanici su podijeljeni prema NAFLD statusu u dvije skupine koje su zatim uspoređivane s obzirom na prisutnost komponenata metaboličkog sindroma. Rezultati su naposlijetku stavljeni u kontekst dostupne literature.

Abstract (english)

Metabolic syndrome and fatty liver are common metabolic disorders that carry significant cardiovascular risk and risk for chronic liver disease. These two entities are intertwined in a network of pathophysiological mechanisms that lead to modulation of the immune response, which could be the basis for an increased risk of infections. The aim of this study was to investigate this relationship and determine the prevalence of metabolic syndrome components and fatty liver in hospitalized patients with severe bacterial infections. This is a cross-sectional study conducted on 319 patients hospitalized at the Clinic for Infectious Diseases “Dr. Fran Mihaljević" from January to December 2022. In addition to recording the frequency of the mentioned conditions, the participants were grouped according to age, gender, clinical syndrome, degree of steatosis and fibrosis. Total prevalences and prevalences per clinical syndrome were calculated for individual components of metabolic syndrome and NAFLD. The participants were divided into two groups based on NAFLD status, which were then compared regarding the presence of metabolic syndrome components. The results were ultimately contextualised with the available literature.

• Keywords: metabolički sindrom; masna jetra; NAFLD; bakterijske infekcije
• Keywords (english): metabolic syndrome; fatty liver; NAFLD; bacterial infections
• Language: croatian
• URN:NBN: urn:nbn:hr:105:575985
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-25 12:20:15