Usporedba učinka kirurške i perkutane zamjene valvule na smanjenje maksimalnog transvalvularnog gradijenta tlaka u bolesnika s aortnom stenozom

master's thesis

• Title (english): Comparison of effects of surgical and percutaneous valve replacement on reduction of maximal transvalvular pressure gradient in aortic stenosis patients
• Author: Vesna Pečevski
• Mentor: Eduard Margetić (mentor)
• Committee member: Martina Lovrić Benčić (predsjednik povjerenstva)
• Committee member: Boško Skorić (član povjerenstva)
• Committee member: Eduard Margetić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

UVOD: Cilj ovog istraživanja bio je usporediti učinak liječenja aortne stenoze kirurškom i perkutanom zamjenom valvule analizirajući smanjenje maksimalnog transvalvularnog gradijenta tlaka (maks. PG).

ISPITANICI I METODE: Ovo retrospektivno istraživanje provedeno je na 415 bolesnika s dijagnozom aortne stenoze koji su liječeni kiruškom ili perkutanom zamjenom valvule od početka 2017. do kraja 2022. godine u Kliničkom bolničkom centru Zagreb. Podaci su prikupljeni iz bolničkog informacijskog... More sutava (BIS-a) i „EchoPAC“ programa. Bolesnici su podijeljeni u dvije skupine: oni liječeni kirurškom zamjenom zaliska (SAVR) te oni liječeni perkutanom zamjenom (TAVI), a analizirani su im dob, spol, komorbiditeti i ehokardiografski parametri (maks. PG i EFLV).

REZULTATI: Od ukupnog broja ispitanika, 209 ih je bilo podvrgnuto kirurškoj zamjeni valvule, a 206 perkutanoj. Bolesnici liječeni TAVI-jem bili su značajno stariji (prosječno 80,3 godina) nego kirurški (prosječno 68,7 godina; p<0,001). Ustanovljeno je učinkovitije smanjenje maks. PG-a u TAVI skupini u odnosu na SAVR (73,2% i 65,4%, respektivno; p<0,001). Također, uočene su niže vrijednosti maks. PG-a nakon zahvata u TAVI skupini (p<0,001), kao i njegovo učinkovitije smanjenje s porastom dobi u toj skupini. Vrijednost ejekcijske frakcije povećala se u većem postotku bolesnika nakon TAVI zahvata (61,7%) u usporedbi s kirurškim zahvatom (48,8%; p=0,029). Statističkom analizom nije pokazana korelacija između kretanja vrijednosti EFLV-a i stupnja smanjenja maks. PG-a nakon zahvata (p=0,913).

ZAKLJUČAK: Obzirom na smanjenje maks. PG-a nakon intervencije, perkutana zamjena valvule pokazala se učinkovitijom metodom u liječenju bolesnika s AS nego kirurška zamjena. Less

Abstract (english)

INTRODUCTION: The aim of this study was to compare the treatment effect of aortic stenosis through surgical and percutaneous valve replacement by analyzing the reduction of maximal transvalvular pressure gradient.

PATIENTS AND METHODS: This retrospective study included 415 patients diagnosed with aortic stenosis who underwent surgical or percutaneous valve replacement from the beginning of 2017 to the end of 2022 at the Clinical Hospital Center Zagreb. The data were extracted from the... More hospital digital database and the "EchoPAC" program. The patients were divided into two groups: those treated with surgical aortic valve replacement (SAVR) and those treated with transcatheter aortic valve replacement (TAVI). Their age, gender, comorbidities and echocardiographic parameters (max. PG and EFLV) were analyzed.

RESULTS: Out of the total number of patients, 209 underwent surgical valve replacement, while 206 underwent percutaneous valve replacement. Patients treated with TAVI were significantly older (mean age 80,3 years) compared to the surgical group (mean age 68,7 years; p<0.001). A more effective reduction of maximal transvalvular pressure gradient was observed in the TAVI group compared to SAVR (73.2% and 65.4% respectively; p<0.001). Additionally, lower values of max. PG were observed after the procedure in the TAVI group (p<0.001), as well as a more effective reduction with increasing age in that group. The ejection fraction value increased in a higher percentage of patients after TAVI procedure (61.7%) compared to surgical intervention (48.8%; p=0.029). Statistical analysis did not show a correlation between the change in EFLV values and the degree of reduction of max. PG after the procedure (p=0,913).

CONCLUSION: Considering the reduction of max. PG after the procedure, transcatheter valve replacement has shown to be a more effective method in treating patients with aortic stenosis compared to surgical replacement. Less

• Keywords: aortna stenoza; kirurška zamjena valvule; maksimalni transvalvularni gradijent tlaka; perkutana zamjena valvule
• Keywords (english): aortic stenosis; maximal transvalvular pressure gradient; percutaneous valve replacement; surgical valve replacement
• Language: croatian
• URN:NBN: urn:nbn:hr:105:313971
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-27 10:55:59