Akutizacija kroničnog zatajenja jetre (ACLF) i transplantacija jetre

master's thesis

• Title (english): Acute-on-chronic liver failure and liver transplantation
• Author: Nika Petković
• Mentor: Nikola Sobočan (mentor)
• Committee member: Tajana Filipec Kanižaj (predsjednik povjerenstva)
• Committee member: Ivana Vuković Brinar (član povjerenstva)
• Committee member: Nikola Sobočan (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2023-09-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Akutizacija kroničnog zatajenja jetre (ACLF) je sindrom koji obuhvaća akutnu dekompenzaciju već postojeće, kronične, bolesti jetre, zatajenje ekstrahepatalnih organa te visoku stopu mortaliteta u kratkom vremenu. Točan mehanizam nastanka ACLF-a nije poznat, ali smatra se da je u pozadini istoga sistemska upala. Prema CLIF-C OF bodovnom sustavu ACLF se grupira u 3 stadija. Kako bi se procijenila težina bolesti primjenjuju se dvije grupe bodovnih sustava, specifični za jetru te oni koji se koriste u JIL-u. MELD-Na bodovni sustav primjenjuje se u svrhe procjene prioriteta među kandidatima za transplantaciju. Ne postoji specifično liječenje ACLF-a, već se liječenje sastoji od liječenja precipitirajućih čimbenika i potpornog liječenja. Transplantacija jetre najbolja je opcija pacijentima s ACLF-om koja poboljšava prognozu preživljenja.

Abstract (english)

Acute-on-chronic liver failure is a syndrome that combines acute decompensation of liver disease, extrahepatic organ failure and high risk of short-term mortality rate. The exact mechanism of the ACLF is not known but it is considered that in the background of the ACLF is systemic inflammation. There are 3 grades of the ACLF according to CLIF-C OF score. To assess the severity of the ACLF there are two groups of scores that are used, and they are liver specific scores and those used in the ICU. The MELD-Na score system applies for the purpose to asses' priorities among transplantation candidates. The specific treatment for the ACLF is unknown but the therapy includes treatment of precipitating factors and organ suport therapy. Liver transplantation is the best option that improves survival prognosis in the patients with ACLF.

• Keywords: ACLF; prognostički bodovni sustavi; liječenje; transplantacija jetre
• Keywords (english): ACLF; prognostic scoring systems; treatment; liver transplantation
• Language: croatian
• URN:NBN: urn:nbn:hr:105:668204
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-30 09:28:04