Depresija u onkoloških bolesnika

master's thesis

• Title (english): Depression in oncology patients
• Author: Ivona Renić
• Mentor: Marina Šagud (mentor)
• Committee member: Darko Marčinko (predsjednik povjerenstva)
• Committee member: Dražen Begić (član povjerenstva)
• Committee member: Marina Šagud (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Psychiatry and Psychological Medicine); Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry

Abstract

Depresija je poremećaj raspoloženja koji se nalazi na četvrtom mjestu po učestalosti bolesti u svijetu. To stanje obilježeno je mnogim psihičkim simptomima povezanim sa sniženim raspoloženjem, negativnim pogledom na sebe i svijet te nedostatkom volje. Postoje razne teorije nastanka ove bolesti, no vjeruje se da je etiologija rezultat djelovanja više čimbenika. Dijagnoza ovog poremećaja temelji se na kriterijima koji moraju biti ispunjeni, a odnose se na količinu depresivnih simptoma i njihovo trajanje. U liječenju postoji više mogućnosti poput psihoterapije, farmakoterapije, elektrokonvulzivne terapije te drugih metoda kao što je promjena životnih navika. Adekvatno liječenje uvelike pospješuje borbu protiv ove bolesti. Depresija se često može javiti kao komorbiditet uz druge kronične bolesti pa tako i uz maligne. Maligne bolesti su same po sebi nepredvidive, izazivaju strah i anksioznost te imaju vrlo jak utjecaj na psihičko stanje osobe. Bolesnici koji istovremeno boluju i od depresije imaju dokazano lošiji odgovor na liječenje, produljuje se vrijeme boravka u bolnici te je sama prognoza zloćudne bolesti lošija. Teoriju nastanka depresije u ovih bolesnika podupiru razni biološki koncepti kao i utjecaj samog stresa. U liječenju ovih pacijenata valja biti posebno oprezan s obzirom na moguće interakcije antidepresiva i drugih lijekova te na promijenjene farmakodinamiku i farmakokinetiku. Psihoterapija igra iznimno važnu ulogu jer pomaže u prilagodbi bolesnika, njegovu suočavanju s bolešću te u terapiji boli koja je ovdje neizostavna. Ključan je cjelovit pristup pacijentu kako bi se na vrijeme prepoznao psihički poremećaj te se adekvatno pristupilo njegovu liječenju zajedno uz osnovnu bolest.

Abstract (english)

Depression is a mood disorder that ranks fourth in terms of the frequency of illnesses worldwide. This condition is characterized by various psychological symptoms associated with low mood, negative self-perception, a negative view of the world, and a lack of motivation. There are various theories regarding the onset of this condition, but it is believed to be the result of multiple factors. The diagnosis of this disorder is based on criteria that must be met, relating to the quantity and duration of depressive symptoms. Treatment options include psychotherapy, pharmacotherapy, electroconvulsive therapy, and other methods such as lifestyle changes. Adequate treatment greatly enhances the fight against this illness. Depression often co-occurs with other chronic diseases, including malignancies. Malignant diseases themselves are unpredictable, causing fear and anxiety and having a profound impact on a person's mental state. Patients who simultaneously suffer from depression and malignancies have been proven to have a poorer response to treatment, prolonged hospital stays, and a worse prognosis for the malignant disease itself. The theory of depression onset in these patients is supported by various biological concepts, as well as the influence of stress itself. When treating these patients, caution must be exercised regarding possible interactions between antidepressants and other medications, as well as altered pharmacodynamics and pharmacokinetics. Psychotherapy plays an extremely important role as it helps patients adapt, cope with the illness, and manage the inevitable pain. A comprehensive approach to the patient is crucial in order to timely recognize the mental disorder and adequately address its treatment alongside the underlying disease.

• Keywords: depresija; maligna bolest; komorbiditet; antidepresivi; psihoterapija
• Keywords (english): depression; malignant disease; comorbidity; antidepressants; psychotherapy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:186726
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-30 11:51:25