prikaz prve stranice dokumenta Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database
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Scientific paper - Original scientific paper
Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database
European Radiology, 33 (2023), 8; 5400-5410. https://doi.org/10.1007/s00330-023-09675-0
Bickel, Hubert; Clauser, Paola; Pinker, Katja; Helbich, Thomas; Biondić, Iva; Brkljačić, Boris; Dietzel, Matthias; Ivanac, Gordana; Krug, Barbara; Moschetta, Marco; Neuhaus, Victor; Preidler, Klaus; Baltzer, Pascal

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Bickel, H., Clauser, P., Pinker, K., Helbich, T., Biondić, I., Brkljačić, B. ... Baltzer, P. (2023). Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database. European Radiology, 33. (8), 5400-5410. doi: 10.1007/s00330-023-09675-0

Bickel, Hubert, et al. "Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database." European Radiology, vol. 33, no. 8, 2023, pp. 5400-5410. https://doi.org/10.1007/s00330-023-09675-0

Bickel, Hubert, Paola Clauser, Katja Pinker, Thomas Helbich, Iva Biondić, Boris Brkljačić, Matthias Dietzel, et al. "Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database." European Radiology 33, no. 8 (2023): 5400-5410. https://doi.org/10.1007/s00330-023-09675-0

Bickel, H., et al. (2023) 'Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database', European Radiology, 33(8), pp. 5400-5410. doi: 10.1007/s00330-023-09675-0

Bickel H, Clauser P, Pinker K, Helbich T, Biondić I, Brkljačić B, and sur.. Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database. European Radiology [Internet]. 2023 August [cited 2024 May 04];33(8):5400-5410. doi: 10.1007/s00330-023-09675-0

H. Bickel, et al., "Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database", European Radiology, vol. 33, no. 8, pp. 5400-5410, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:543722. [Accessed: 04 May 2024]

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Metadata
Title (english)Introduction of a breast apparent diffusion coefficient category system (ADC-B) derived from a large multicenter MRI database
AuthorHubert Bickel
AuthorPaola Clauser
AuthorKatja Pinker
AuthorThomas Helbich
AuthorIva Biondić
AuthorBoris Brkljačić
AuthorMatthias Dietzel
AuthorGordana Ivanac
AuthorBarbara Krug
AuthorMarco Moschetta
AuthorVictor Neuhaus
AuthorKlaus Preidler
AuthorPascal Baltzer
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Radiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Radiology
Abstract (english)
Objectives: To develop an intuitive and generally applicable system for the reporting, assessment, and documentation of ADC to complement standard BI-RADS criteria. Methods: This was a multicentric, retrospective analysis of 11 independently conducted institutional review board-approved studies from seven institutions performed between 2007 and 2019. Breast Apparent Diffusion coefficient (ADC-B) categories comprised ADC-B0 (ADC non-diagnostic), ADC-B1 (no enhancing lesion), and ADC-B2-5. The latter was defined by plotting ADC versus cumulative malignancy rates. Statistics comprised ANOVA with post hoc testing and ROC analysis. p values ≤ 0.05 were considered statistically significant. Results: A total of 1625 patients (age: 55.9 years (± 13.8)) with 1736 pathologically verified breast lesions were included. The mean ADC (× 10-3 mm2/s) differed significantly between benign (1.45, SD .40) and malignant lesions (.95, SD .39), and between invasive (.92, SD .22) and in situ carcinomas (1.18, SD .30) (p < .001). The following ADC-B categories were identified: ADC-B0-ADC cannot be assessed; ADC-B1-no contrast-enhancing lesion; ADC-B2-ADC ≥ 1.9 (cumulative malignancy rate < 0.1%); ADC-B3-ADC 1.5 to < 1.9 (0.1-1.7%); ADC-B4-ADC 1.0 to < 1.5 (10-24.5%); and ADC-B5-ADC < 1.0 (> 24.5%). At the latter threshold, a positive predictive value of 95.8% (95% CI 0.94-0.97) for invasive versus non-invasive breast carcinomas was reached. Conclusions: The breast apparent diffusion coefficient system (ADC-B) provides a simple and widely applicable categorization scheme for assessment, documentation, and reporting of apparent diffusion coefficient values in contrast-enhancing breast lesions on MRI. Clinical relevance statement: The ADC-B system, based on diverse MRI examinations, is clinically relevant for stratifying breast cancer risk via apparent diffusion coefficient measurements, and complements BI-RADS for improved clinical decision-making and patient outcomes
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEuropean Radiology
Numberingvol. 33, no. 8, pp. 5400-5410
e-ISSN1432-1084
DOIhttps://doi.org/10.1007/s00330-023-09675-0
URN:NBNurn:nbn:hr:105:543722
Publication2023-08
Document URLhttps://link.springer.com/10.1007/s00330-023-09675-0
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-11-03 09:39:06