prikaz prve stranice dokumenta Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT
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Scientific paper - Original scientific paper
Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT
Bone Marrow Transplantation, 58 (2023), 8; 874-880. https://doi.org/10.1038/s41409-023-01966-w
Hirschbühl, Klaus; Labopin, Myriam; Polge, Emmanuelle; Blaise, Didier; Bourhis, Jean Henri; Socié, Gerard; Forcade, Edouard; Yakoub-Agha, Ibrahim; Labussière-Wallet, Hélène; Bethge, Wolfgang; Chevallier, Patrice; Bonnet, Sarah; Stelljes, Matthias; Spyridonidis, Alexandros; Perić, Zinaida; Brissot, Eolia; Savani, Bipin; Giebel, Sebastian; Schmid, Christoph; Ciceri, Fabio; Nagler, Arnon; Mohty, Mohamad More authors...

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Hirschbühl, K., Labopin, M., Polge, E., Blaise, D., Bourhis, J. H., Socié, G. ... Mohty, M. (2023). Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT. Bone Marrow Transplantation, 58. (8), 874-880. doi: 10.1038/s41409-023-01966-w

Hirschbühl, Klaus, et al. "Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT." Bone Marrow Transplantation, vol. 58, no. 8, 2023, pp. 874-880. https://doi.org/10.1038/s41409-023-01966-w

Hirschbühl, Klaus, Myriam Labopin, Emmanuelle Polge, Didier Blaise, Jean Henri Bourhis, Gerard Socié, Edouard Forcade, et al. "Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT." Bone Marrow Transplantation 58, no. 8 (2023): 874-880. https://doi.org/10.1038/s41409-023-01966-w

Hirschbühl, K., et al. (2023) 'Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT', Bone Marrow Transplantation, 58(8), pp. 874-880. doi: 10.1038/s41409-023-01966-w

Hirschbühl K, Labopin M, Polge E, Blaise D, Bourhis JH, Socié G, and sur.. Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT. Bone Marrow Transplantation [Internet]. 2023 August [cited 2024 May 05];58(8):874-880. doi: 10.1038/s41409-023-01966-w

K. Hirschbühl, et al., "Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT", Bone Marrow Transplantation, vol. 58, no. 8, pp. 874-880, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:511899. [Accessed: 05 May 2024]

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Title (english)Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years - a registry-based study by the Acute Leukemia Working Party of the EBMT
AuthorKlaus Hirschbühl
AuthorMyriam Labopin
AuthorEmmanuelle Polge
AuthorDidier Blaise
AuthorJean Henri Bourhis
AuthorGerard Socié
AuthorEdouard Forcade
AuthorIbrahim Yakoub-Agha
AuthorHélène Labussière-Wallet
AuthorWolfgang Bethge
AuthorPatrice Chevallier
AuthorSarah Bonnet
AuthorMatthias Stelljes
AuthorAlexandros Spyridonidis
AuthorZinaida Perić
AuthorEolia Brissot
AuthorBipin Savani
AuthorSebastian Giebel
AuthorChristoph Schmid
AuthorFabio Ciceri
AuthorArnon Nagler
AuthorMohamad Mohty
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Allogeneic hematopoietic cell transplantation is a potentially curative treatment in high-risk acute lymphoblastic leukemia (ALL). Conditioning regimens based on ≥12 Gray total body irradiation (TBI) represent the current standard in patients ≤45 years, whereas elderly patients frequently receive intermediate intensity conditioning (IIC) to reduce toxicity. To evaluate the role of TBI as a backbone of IIC in ALL, a retrospective, registry-based study included patients >45 years transplanted from matched donors in first complete remission, who had received either fludarabine/TBI 8 Gy (FluTBI8, n = 262), or the most popular, irradiation-free alternative fludarabine/busulfan, comprising busulfan 6.4 mg/kg (FluBu6.4, n = 188) or 9.6 mg/kg (FluBu9.6, n = 51). At two years, overall survival (OS) was 68.5%, 57%, and 62.2%, leukemia-free survival (LFS) was 58%, 42.7%, and 45%, relapse incidence (RI) was 27.2%, 40%, and 30.9%, and non-relapse-mortality (NRM) was 23.1%, 20.7%, and 26.8% for patients receiving FluTBI8Gy, FluBu6.4, and FluBu9.6, respectively. In multivariate analysis, the risk of NRM, acute and chronic graft-versus-host disease was not influenced by conditioning. However, RI was higher after FluBu6.4 (hazard ratio [HR] [95% CI]: 1.85 [1.16-2.95]), and LFS was lower after both FluBu6.4 (HR: 1.56 [1.09-2.23]) and FluBu9.6 (HR: 1.63 [1.02-2.58]) as compared to FluTBI8. Although only resulting in a non-significant advantage in OS, this observation indicates a stronger anti-leukemic efficacy of TBI-based intermediate intensity conditioning.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBone Marrow Transplantation
Numberingvol. 58, no. 8, pp. 874-880
p-ISSN0268-3369
e-ISSN1476-5365
DOIhttps://doi.org/10.1038/s41409-023-01966-w
URN:NBNurn:nbn:hr:105:511899
Publication2023-08
Document URLhttps://www.nature.com/articles/s41409-023-01966-w
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-11-09 11:50:24