Complex open and endovascular reconstructions of aorta and its branches

master's thesis

• Title (croatian): Složene otvorene i endovaskularne rekonstrukcije aorte i njezinih ogranaka
• Author: Maor Meir Pichadze
• Mentor: Tomislav Meštrović (mentor)
• Committee member: Tomislav Meštrović (predsjednik povjerenstva)
• Committee member: Predrag Pavić (član povjerenstva)
• Committee member: Boško Skorić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery

Abstract

The aorta is the largest blood vessel in the human body, responsible for supplying blood for the systemic circulation and enabling the blood supply to the organs via its branches. Aortic diseases are of major global concern since the history of humankind, though, their significance is even more pronounced nowadays in developed countries, due to the additive and synergistic effects of natural physiologic factors combined with various risk factors that emerged with the transition to the current sedentary western lifestyle (smoking, western diet, less physical activity, etc.) worldwide. The nature of the aging process together with those behaviors might, in turn, cause significant pathologic changes in the aortic anatomy and histology, facilitating the development of various pathological processes, which emphasizes the need for research in the field of the aorta and aortic branches reconstruction.
The pathophysiological processes causing aortic disease can be interrupted or decelerated via the use of medical treatment modalities and lifestyle changes, though, research and practical experience in the field teach us that, past a certain point, surgical or endovascular reconstruction of the aorta will warrant better results in managing such patients.
Aorta and its branches can be reconstructed surgically via the established open surgical approach, or via the relatively modern endovascular and hybrid approaches. The open surgical approach allows for excellent durability and a large field of view compared to the endovascular approach which has the advantages of decreased trauma, faster recovery with lower early complication rate, and shorter postoperative hospital stay.

Abstract (english)

Aorta je najveća krvna žila u ljudskom tijelu, odgovorna za opskrbu sistemske cirkulacije, koja svojim ograncima omogućuje opskrbu tjelesnih organa krvlju. Bolesti aorte predstavljaju veliku globalni problem od povijesti ljudske vrste, no njihov je značaj još izraženiji u razvijenim zemljama današnjice zbog aditivnih i sinergijskih učinaka prirodnih fizioloških čimbenika u kombinaciji s različitim čimbenicima rizika koji su se pojavili s prijelazom na sadašnji sjedilački zapadnjački stil života (pušenje, zapadnjačka prehrana, nedostatak tjelesne aktivnosti itd.) diljem svijeta. Priroda procesa starenja zajedno sa suvremenim stilom života može zauzvrat uzrokovati značajne patološke promjene u anatomiji i histologiji aorte i prouzročiti razvoj različitih patoloških procesa, što uzrokuje potrebu za istraživanjima u području rekonstrukcije aorte i njenih ogranaka.
Patofiziološki procesi koji uzrokuju bolesti aorte mogu se prekinuti ili usporiti primjenom medicinskih modaliteta liječenja i modifikacijom stila života, međutim, istraživanja i iskustvo u praksi pokazuje da će, progresijom bolesti, nakon određene točke, kirurška ili endovaskularna rekonstrukcija aorte jamčiti bolje rezultate u liječenju takvih bolesnika.
Aorta i njezine grane mogu se kirurški rekonstruirati klasičnim otvorenim kirurškim pristupom ili relativno modernim endovaskularnim i hibridnim pristupima. Otvoreni kirurški pristup omogućuje izvrsnu izdržljivost i veliko vidno polje u usporedbi s endovaskularnim pristupom, koji ima za prednost manju traumu, manje ranih poslijeoperacijskih komplikacija, brži oporavak i kraće trajanje hospitalizacije nakon operacije.

• Keywords: open; endovascular; aorta; reconstruction; surgical.
• Keywords (english): otvorena; endovaskularna; aorta; rekonstrukcija; kirurška
• Language: english
• URN:NBN: urn:nbn:hr:105:305801
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-12-12 07:48:16