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Scientific paper - Original scientific paper
Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study
Microorganisms, 11 (2023), 3; 774. https://doi.org/10.3390/microorganisms11030774
Dobrović, Karolina; Škrobo, Tea; Selec, Katarina; Jelić, Marko; Čivljak, Rok; Peršec, Jasminka; Sakan, Sanja; Bušić, Nikolina; Mihelčić, Antonija; Hleb, Sonja; Tambić Andrašević, Arjana

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Dobrović, K., Škrobo, T., Selec, K., Jelić, M., Čivljak, R., Peršec, J. ... Tambić Andrašević, A. (2023). Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study. Microorganisms, 11. (3). doi: 10.3390/microorganisms11030774

Dobrović, Karolina, et al. "Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study." Microorganisms, vol. 11, no. 3, 2023. https://doi.org/10.3390/microorganisms11030774

Dobrović, Karolina, Tea Škrobo, Katarina Selec, Marko Jelić, Rok Čivljak, Jasminka Peršec, Sanja Sakan, et al. "Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study." Microorganisms 11, no. 3 (2023). https://doi.org/10.3390/microorganisms11030774

Dobrović, K., et al. (2023) 'Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study', Microorganisms, 11(3). doi: 10.3390/microorganisms11030774

Dobrović K, Škrobo T, Selec K, Jelić M, Čivljak R, Peršec J, and sur.. Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study. Microorganisms [Internet]. 2023 March 17 [cited 2024 April 12];11(3). doi: 10.3390/microorganisms11030774

K. Dobrović, et al., "Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study", Microorganisms, vol. 11, no. 3, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:292293. [Accessed: 12 April 2024]

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Metadata
Title (english)Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study
AuthorKarolina Dobrović
AuthorTea Škrobo
AuthorKatarina Selec
AuthorMarko Jelić
AuthorRok Čivljak
AuthorJasminka Peršec
AuthorSanja Sakan
AuthorNikolina Bušić
AuthorAntonija Mihelčić
AuthorSonja Hleb
AuthorArjana Tambić Andrašević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
Healthcare-associated infections are an emerging cause of morbidity and mortality in COVID-19 intensive care units (ICUs) worldwide, especially those caused by multidrug-resistant (MDR) pathogens. The objectives of this study were to assess the incidence of bloodstream infections (BSIs) among critically ill COVID-19 patients and to analyze the characteristics of healthcare-associated BSIs due to MDR Acinetobacter baumannii in an COVID-19 ICU. A single-center retrospective study was conducted at a tertiary hospital during a 5-month period. The detection of carbapenemase genes was performed by PCR and genetic relatedness by pulsed-field gel electrophoresis (PFGE) and multilocus-sequence typing. A total of 193 episodes were registered in 176 COVID-19 ICU patients, with an incidence of 25/1000 patient-days at risk. A. baumannii was the most common etiological agent (40.3%), with a resistance to carbapenems of 100%. The blaOXA-23 gene was detected in ST2 isolates while the blaOXA-24 was ST636-specific. PFGE revealed a homogeneous genetic background of the isolates. The clonal spread of OXA-23-positive A. baumannii is responsible for the high prevalence of MDR A. baumannii BSIs in our COVID-19 ICU. Further surveillance of resistance trends and mechanisms is needed along with changes in behavior to improve the implementation of infection control and the rational use of antibiotics.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMicroorganisms
Numberingvol. 11, no. 3, 774
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms11030774
URN:NBNurn:nbn:hr:105:292293
Publication2023-03-17
Document URLhttps://www.mdpi.com/2076-2607/11/3/774
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-08 09:50:47