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Scientific paper - Original scientific paper
The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder
International Journal of Molecular Sciences, 24 (2023), 6; 5706. https://doi.org/10.3390/ijms24065706
Tudor, Lucija; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Konjevod, Marcela; Uzun, Suzana; Kozumplik, Oliver; Mimica, Ninoslav; Lauc, Gordan; Švob Štrac, Dubravka; Pivac, Nela

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Tudor, L., Nedić Erjavec, G., Nikolac Perković, M., Konjevod, M., Uzun, S., Kozumplik, O. ... Pivac, N. (2023). The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder. International Journal of Molecular Sciences, 24. (6). doi: 10.3390/ijms24065706

Tudor, Lucija, et al. "The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder." International Journal of Molecular Sciences, vol. 24, no. 6, 2023. https://doi.org/10.3390/ijms24065706

Tudor, Lucija, Gordana Nedić Erjavec, Matea Nikolac Perković, Marcela Konjevod, Suzana Uzun, Oliver Kozumplik, Ninoslav Mimica, Gordan Lauc, Dubravka Švob Štrac and Nela Pivac. "The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder." International Journal of Molecular Sciences 24, no. 6 (2023). https://doi.org/10.3390/ijms24065706

Tudor, L., et al. (2023) 'The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder', International Journal of Molecular Sciences, 24(6). doi: 10.3390/ijms24065706

Tudor L, Nedić Erjavec G, Nikolac Perković M, Konjevod M, Uzun S, Kozumplik O, and sur.. The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder. International Journal of Molecular Sciences [Internet]. 2023 March 16 [cited 2024 April 20];24(6). doi: 10.3390/ijms24065706

L. Tudor, et al., "The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder", International Journal of Molecular Sciences, vol. 24, no. 6, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:949087. [Accessed: 20 April 2024]

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Metadata
Title (english)The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder
AuthorLucija Tudor
AuthorGordana Nedić Erjavec
AuthorMatea Nikolac Perković
AuthorMarcela Konjevod
AuthorSuzana Uzun
AuthorOliver Kozumplik
AuthorNinoslav Mimica
AuthorGordan Lauc
AuthorDubravka Švob Štrac
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
The molecular underpinnings of post-traumatic stress disorder (PTSD) are still unclear due to the complex interactions of genetic, psychological, and environmental factors. Glycosylation is a common post-translational modification of proteins, and different pathophysiological states, such as inflammation, autoimmune diseases, and mental disorders including PTSD, show altered N-glycome. Fucosyltransferase 8 (FUT8) is the enzyme that catalyzes the addition of core fucose on glycoproteins, and mutations in the FUT8 gene are associated with defects in glycosylation and functional abnormalities. This is the first study that investigated the associations of plasma N-glycan levels with FUT8-related rs6573604, rs11621121, rs10483776, and rs4073416 polymorphisms and their haplotypes in 541 PTSD patients and control participants. The results demonstrated that the rs6573604 T allele was more frequent in the PTSD than in the control participants. Significant associations of plasma N-glycan levels with PTSD and FUT8-related polymorphisms were observed. We also detected associations of rs11621121 and rs10483776 polymorphisms and their haplotypes with plasma levels of specific N-glycan species in both the control and PTSD groups. In carriers of different rs6573604 and rs4073416 genotypes and alleles, differences in plasma N-glycan levels were only found in the control group. These molecular findings suggest a possible regulatory role of FUT8-related polymorphisms in glycosylation, the alternations of which could partially explain the development and clinical manifestation of PTSD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 6, 5706
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24065706
URN:NBNurn:nbn:hr:105:949087
Publication2023-03-16
Document URLhttps://www.mdpi.com/1422-0067/24/6/5706
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-08 12:20:14