prikaz prve stranice dokumenta Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies
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Scientific paper - Review paper
Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies
Gynecological Endocrinology, 39 (2023), 1; 2190806. https://doi.org/10.1080/09513590.2023.2190806
Pitner, Iva; Mikuš, Mislav; Šprem Goldštajn, Marina; Laganà, Antonio Simone; Chiantera, Vito; Ferrari, Federico; Shah, Mohsin; D’Alterio, Maurizio Nicola; Vitale, Salvatore Giovanni; Angioni, Stefano

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Pitner, I., Mikuš, M., Šprem Goldštajn, M., Laganà, A. S., Chiantera, V., Ferrari, F. ... Angioni, S. (2023). Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies. Gynecological Endocrinology, 39. (1). doi: 10.1080/09513590.2023.2190806

Pitner, Iva, et al. "Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies." Gynecological Endocrinology, vol. 39, no. 1, 2023. https://doi.org/10.1080/09513590.2023.2190806

Pitner, Iva, Mislav Mikuš, Marina Šprem Goldštajn, Antonio Simone Laganà, Vito Chiantera, Federico Ferrari, Mohsin Shah, Maurizio Nicola D’Alterio, Salvatore Giovanni Vitale and Stefano Angioni. "Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies." Gynecological Endocrinology 39, no. 1 (2023). https://doi.org/10.1080/09513590.2023.2190806

Pitner, I., et al. (2023) 'Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies', Gynecological Endocrinology, 39(1). doi: 10.1080/09513590.2023.2190806

Pitner I, Mikuš M, Šprem Goldštajn M, Laganà AS, Chiantera V, Ferrari F, and sur.. Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies. Gynecological Endocrinology [Internet]. 2023 March 24 [cited 2025 January 04];39(1). doi: 10.1080/09513590.2023.2190806

I. Pitner, et al., "Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies", Gynecological Endocrinology, vol. 39, no. 1, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:549237. [Accessed: 04 January 2025]

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Metadata
Title (english)Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies
AuthorIva Pitner
AuthorMislav Mikuš
AuthorMarina Šprem Goldštajn
AuthorAntonio Simone Laganà
AuthorVito Chiantera
AuthorFederico Ferrari
AuthorMohsin Shah
AuthorMaurizio Nicola D’Alterio
AuthorSalvatore Giovanni Vitale
AuthorStefano Angioni
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Gynecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Purpose: The aim of this narrative review is to offer an overview about the role of progesterone levels on pregnancy outcome in patients undergoing assisted reproductive technologies (ARTs). Methods: A detailed computerized search of the literature was performed in the main electronic databases (MEDLINE, EMBASE, Web of Science) to determine the importance of elevated progesterone levels at different stages of the cycle for pregnancy rates in the in vitro fertilization (IVF) cycle. Our review also provides information on the differences between elevated progesterone levels and their interpretation in normal and in poorly responding women. Results: After careful evaluation, our search strategy yielded a total of 15 included articles, showing the possible factors that may have had an impact on the increased progesterone level before human chorionic gonadotropin (HCG) injection and the different thresholds above which the pregnancy rate was lower. Furthermore, increased progesterone on cycle day 2 or 3 could serve as a marker for increased progesterone in the late follicular phase, which is associated with a lower pregnancy rate. Conclusion: Despite the literature data that support the negative effect of elevated progesterone on fresh cycles, due to lack of randomized controlled trials, the value of measuring progesterone in daily practice is questionable. Available evidence supports the detrimental effect of elevated progesterone in different subgroups of women, although there is still the need for defining different thresholds and durations of high progesterone exposure. The need for various thresholds for different cohorts of women, the inter-assay variability is making this decision harder.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleGynecological Endocrinology
Numberingvol. 39, no. 1, 2190806
p-ISSN0951-3590
e-ISSN1473-0766
DOIhttps://doi.org/10.1080/09513590.2023.2190806
URN:NBNurn:nbn:hr:105:549237
Publication2023-03-24
Document URLhttps://www.tandfonline.com/doi/full/10.1080/09513590.2023.2190806
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-09 09:04:05