Markers of cardiac injury in patients with liver cirrhosis

Scientific paper - Review paper

• Author: Stjepan Šimić
• Author: Tomo Svaguša
• Author: Ivica Grgurević
• Author: Sanda Mustapić
• Author: Marko Žarak
• Author: Ingrid Prkačin
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (english)

Liver cirrhosis is an increasing public health problem and a major cause of morbidity and mortality. Accordingly, cirrhotic cardiomyopathy, a frequently underdiagnosed condition, is becoming a growing health problem. In the last 20 years, cardioselective biomarkers have been investigated for their diagnostic and prognostic properties for numerous conditions. The aim of this article is to review the literature on the relationship between the most commonly used cardioselective biomarkers (cardiac troponins I and T, N-terminal pro-B-type natriuretic peptide, brain natriuretic peptide, and heart-type fatty-acid binding protein) and the presence, functional stage, and clinical outcomes of liver cirrhosis. Elevated plasma levels of these biomarkers have been reported in patients with liver cirrhosis, and there is mounting evidence on their predictive value for clinical outcomes in this disease. In addition, elevated plasma levels of these biomarkers have been reported in patients before, during, and after liver transplantation, but in fewer studies. Due to their predictive value for clinical outcomes, we advocate the use of these markers in patients with liver cirrhosis and cirrhotic cardiomyopathy, as well as in candidates for liver transplant.

• Keywords (english): Biomarkers; Cardiomyopathies / diagnosis; Cardiomyopathies / etiology; Humans; Liver Cirrhosis / complications; Liver Transplantation; Natriuretic Peptide, Brain; Public Health
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Croatian Medical Journal
• Numbering: vol. 64, no. 5, pp. 362-373
• p-ISSN: 0353-9504
• e-ISSN: 1332-8166
• DOI: https://doi.org/10.3325/cmj.2023.64.362
• URN:NBN: urn:nbn:hr:105:773197
• Publication: 2023-10-31
• Document URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668036/
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-01-11 09:43:14