prikaz prve stranice dokumenta Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis
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Scientific paper - Original scientific paper
Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis
Multiple Sclerosis Journal, 29 (2023), 7; 875-883. https://doi.org/10.1177/13524585231151951
Daruwalla, Cyrus; Shaygannejad, Vahid; Ozakbas, Serkan; Havrdova, Eva Kubala; Horakova, Dana; Alroughani, Raed; Boz, Cavit; Patti, Francesco; Onofrj, Marco; Lugaresi, Alessandra; Eichau, Sara; Girard, Marc; Prat, Alexandre; Duquette, Pierre; Yamout, Bassem; Khoury, Samia J; Sajedi, Seyed Aidin; Turkoglu, Recai; Altintas, Ayse; Skibina, Olga; Buzzard, Katherine; Grammond, Pierre; Karabudak, Rana; van der Walt, Anneke; Butzkueven, Helmut; Maimone, Davide; Lechner-Scott, Jeannette; Soysal, Aysun; John, Nevin; Prevost, Julie; Spitaleri, Daniele; Ramo-Tello, Cristina; Gerlach, Oliver; Iuliano, Gerardo; Foschi, Matteo; Ampapa, Radek; van Pesch, Vincent; Barnett, Michael; Shalaby, Nevin; D’hooghe, Marie; Kuhle, Jens; Sa, Maria Jose; Fabis-Pedrini, Marzena; Kermode, Allan; Mrabet, Saloua; Gouider, Riadh; Hodgkinson, Suzanne; Laureys, Guy; Van Hijfte, Liesbeth; Macdonell, Richard; Oreja-Guevara, Celia; Cristiano, Edgardo; McCombe, Pamela; Sanchez-Menoyo, Jose Luis; Singhal, Bhim; Blanco, Yolanda; Hughes, Stella; Garber, Justin; Solaro, Claudio; McGuigan, Chris; Taylor, Bruce; de Gans, Koen; Habek, Mario; Al-Asmi, Abdullah; Mihaela, Simu; Castillo Triviño, Tamara; Al-Harbi, Talal; Rojas, Juan Ignacio; Gray, Orla; Khurana, Dheeraj; Van Wijmeersch, Bart; Grigoriadis, Nikolaos; Inshasi, Jihad; Oh, Jiwon; Aguera-Morales, Eduardo; Fragoso, Yara; Moore, Fraser; Shaw, Cameron; Baghbanian, Seyed Mohammad; Shuey, Neil; Willekens, Barbara; Hardy, Todd A; Decoo, Danny; sempere, Angel Perez; Field, Deborah; Wynford-Thomas, Ray; Cunniffe, Nick G; Roos, Izanne; Malpas, Charles B; Coles, Alasdair J; Kalincik, Tomas; Brown, J William L More authors...

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Daruwalla, C., Shaygannejad, V., Ozakbas, S., Havrdova, E. K., Horakova, D., Alroughani, R. ... Brown, J. W. L. (2023). Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal, 29. (7), 875-883. doi: 10.1177/13524585231151951

Daruwalla, Cyrus, et al. "Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis." Multiple Sclerosis Journal, vol. 29, no. 7, 2023, pp. 875-883. https://doi.org/10.1177/13524585231151951

Daruwalla, Cyrus, Vahid Shaygannejad, Serkan Ozakbas, Eva Kubala Havrdova, Dana Horakova, Raed Alroughani, Cavit Boz, et al. "Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis." Multiple Sclerosis Journal 29, no. 7 (2023): 875-883. https://doi.org/10.1177/13524585231151951

Daruwalla, C., et al. (2023) 'Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis', Multiple Sclerosis Journal, 29(7), pp. 875-883. doi: 10.1177/13524585231151951

Daruwalla C, Shaygannejad V, Ozakbas S, Havrdova EK, Horakova D, Alroughani R, and sur.. Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal [Internet]. 2023 February 27 [cited 2024 April 29];29(7):875-883. doi: 10.1177/13524585231151951

C. Daruwalla, et al., "Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis", Multiple Sclerosis Journal, vol. 29, no. 7, pp. 875-883, February 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:737222. [Accessed: 29 April 2024]

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Metadata
Title (english)Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis
AuthorCyrus Daruwalla
AuthorVahid Shaygannejad
AuthorSerkan Ozakbas
AuthorEva Kubala Havrdova
AuthorDana Horakova
AuthorRaed Alroughani
AuthorCavit Boz
AuthorFrancesco Patti
AuthorMarco Onofrj
AuthorAlessandra Lugaresi
AuthorSara Eichau
AuthorMarc Girard
AuthorAlexandre Prat
AuthorPierre Duquette
AuthorBassem Yamout
AuthorSamia J Khoury
AuthorSeyed Aidin Sajedi
AuthorRecai Turkoglu
AuthorAyse Altintas
AuthorOlga Skibina
AuthorKatherine Buzzard
AuthorPierre Grammond
AuthorRana Karabudak
AuthorAnneke van der Walt
AuthorHelmut Butzkueven
AuthorDavide Maimone
AuthorJeannette Lechner-Scott
AuthorAysun Soysal
AuthorNevin John
AuthorJulie Prevost
AuthorDaniele Spitaleri
AuthorCristina Ramo-Tello
AuthorOliver Gerlach
AuthorGerardo Iuliano
AuthorMatteo Foschi
AuthorRadek Ampapa
AuthorVincent van Pesch
AuthorMichael Barnett
AuthorNevin Shalaby
AuthorMarie D’hooghe
AuthorJens Kuhle
AuthorMaria Jose Sa
AuthorMarzena Fabis-Pedrini
AuthorAllan Kermode
AuthorSaloua Mrabet
AuthorRiadh Gouider
AuthorSuzanne Hodgkinson
AuthorGuy Laureys
AuthorLiesbeth Van Hijfte
AuthorRichard Macdonell
AuthorCelia Oreja-Guevara
AuthorEdgardo Cristiano
AuthorPamela McCombe
AuthorJose Luis Sanchez-Menoyo
AuthorBhim Singhal
AuthorYolanda Blanco
AuthorStella Hughes
AuthorJustin Garber
AuthorClaudio Solaro
AuthorChris McGuigan
AuthorBruce Taylor
AuthorKoen de Gans
AuthorMario Habek
AuthorAbdullah Al-Asmi
AuthorSimu Mihaela
AuthorTamara Castillo Triviño
AuthorTalal Al-Harbi
AuthorJuan Ignacio Rojas
AuthorOrla Gray
AuthorDheeraj Khurana
AuthorBart Van Wijmeersch
AuthorNikolaos Grigoriadis
AuthorJihad Inshasi
AuthorJiwon Oh
AuthorEduardo Aguera-Morales
AuthorYara Fragoso
AuthorFraser Moore
AuthorCameron Shaw
AuthorSeyed Mohammad Baghbanian
AuthorNeil Shuey
AuthorBarbara Willekens
AuthorTodd A Hardy
AuthorDanny Decoo
AuthorAngel Perez sempere
AuthorDeborah Field
AuthorRay Wynford-Thomas
AuthorNick G Cunniffe
AuthorIzanne Roos
AuthorCharles B Malpas
AuthorAlasdair J Coles
AuthorTomas Kalincik
AuthorJ William L Brown
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Background: The prognostic significance of non-disabling relapses in people with relapsing-remitting multiple sclerosis (RRMS) is unclear. Objective: To determine whether early non-disabling relapses predict disability accumulation in RRMS. Methods: We redefined mild relapses in MSBase as 'non-disabling', and moderate or severe relapses as 'disabling'. We used mixed-effects Cox models to compare 90-day confirmed disability accumulation events in people with exclusively non-disabling relapses within 2 years of RRMS diagnosis to those with no early relapses; and any early disabling relapses. Analyses were stratified by disease-modifying therapy (DMT) efficacy during follow-up. Results: People who experienced non-disabling relapses within 2 years of RRMS diagnosis accumulated more disability than those with no early relapses if they were untreated (n = 285 vs 4717; hazard ratio (HR) = 1.29, 95% confidence interval (CI) = 1.00-1.68) or given platform DMTs (n = 1074 vs 7262; HR = 1.33, 95% CI = 1.15-1.54), but not if given high-efficacy DMTs (n = 572 vs 3534; HR = 0.90, 95% CI = 0.71-1.13) during follow-up. Differences in disability accumulation between those with early non-disabling relapses and those with early disabling relapses were not confirmed statistically. Conclusion: This study suggests that early non-disabling relapses are associated with a higher risk of disability accumulation than no early relapses in RRMS. This risk may be mitigated by high-efficacy DMTs. Therefore, non-disabling relapses should be considered when making treatment decisions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMultiple Sclerosis Journal
Numberingvol. 29, no. 7, pp. 875-883
p-ISSN1352-4585
e-ISSN1477-0970
DOIhttps://doi.org/10.1177/13524585231151951
URN:NBNurn:nbn:hr:105:737222
Publication2023-02-27
Document URLhttp://journals.sagepub.com/doi/10.1177/13524585231151951
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-11 12:06:47