A pilot sentinel surveillance system to monitor treatment and treatment outcomes of chronic hepatitis B and C infections in clinical centres in three European countries, 2019

Scientific paper - Original scientific paper

• Author: Anthony Nardone
• Author: Lina Nerlander
• Author: Erika Duffell
• Author: Marta Valenciano
• Author: Maria Buti
• Author: Cristina Marcos-Fosch
• Author: Tatjana Nemeth-Blažić
• Author: Odette Popovici
• Author: Adriana Vince
• Author: Petruta Violeta Filip
• Author: Tajana Filipec
• Author: Mirjana Lana Kosanović Ličina
• Author: Boris Luksic
• Author: Diana Nonković
• Author: Corina Silvia Pop
• Author: Fabiana Radu
• Author: Irina Teodorescu
• Author: Adriana Violeta Topan
• Author's institution: University of Zagreb; School of Medicine; (Department of Infectious Diseases)
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Infectology

Abstract (english)

Background
The World Health Organization European Action Plan 2020 targets for the elimination of viral hepatitis are that > 75% of eligible individuals with chronic hepatitis B (HBV) or hepatitis C (HCV) are treated, of whom > 90% achieve viral suppression.AimTo report the results from a pilot sentinel surveillance to monitor chronic HBV and HCV treatment uptake and outcomes in 2019.
Methods
We undertook retrospective enhanced data collection on patients with a confirmed chronic HBV or HCV infection presenting at one of seven clinics in three countries (Croatia, Romania and Spain) for the first time between 1 January 2019 and 30 June 2019. Clinical records were reviewed from date of first attendance to 31 December 2019 and data on sociodemographics, clinical history, laboratory results, treatment and treatment outcomes were collected. Treatment eligibility, uptake and case outcome were assessed.
Results
Of 229 individuals with chronic HBV infection, treatment status was reported for 203 (89%). Of the 80 individuals reported as eligible for treatment, 51% (41/80) were treated of whom 89% (33/37) had achieved viral suppression. Of 240 individuals with chronic HCV infection, treatment status was reported for 231 (96%). Of 231 eligible individuals, 77% (179/231) were treated, the majority of whom had received direct acting antivirals (99%, 174/176) and had achieved sustained virological response (98%, 165/169).
Conclusion
Treatment targets for global elimination were missed for HBV but not for HCV. A wider European implementation of sentinel surveillance with a representative sample of sites could help monitor progress towards achieving hepatitis control targets.

• Keywords (english): Antiviral Agents / therapeutic use; Hepacivirus; Hepatitis B virus; Hepatitis B / epidemiology; Hepatitis B, Chronic / diagnosis; Hepatitis B, Chronic / drug therapy; Hepatitis B, Chronic / epidemiology; Hepatitis C* / epidemiology; Hepatitis C, Chronic / diagnosis; Hepatitis C, Chronic / drug therapy; Hepatitis C, Chronic / epidemiology; Humans; Retrospective Studies; Sentinel Surveillance; Treatment Outcome
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Eurosurveillance
• Numbering: vol. 28, no. 6, 2200184
• p-ISSN: 1560-7917
• DOI: https://doi.org/10.2807/1560-7917.ES.2023.28.6.2200184
• URN:NBN: urn:nbn:hr:105:468204
• Publication: 2023-02-09
• Document URL: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.6.2200184
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-01-16 09:28:57