Učinak terapije svjetlom na koncentracije moždanoga neurotrofnoga čimbenika u plazmi i interleukina-6 u serumu bolesnika s terapijski rezistentnim depresivnim poremećajem

doctoral thesis

• Title (english): The effect of light therapy on plasma levels of brain-derived neurotrophic factor and serum levels of interleukin-6 in patients with treatment-resistant depression
• Author: Biljana Kosanović Rajačić
• Mentor: Dražen Begić (mentor)
• Committee member: Alma Mihaljević-Peleš (predsjednik povjerenstva)
• Committee member: Igor Filipčić (član povjerenstva)
• Committee member: Nada Božina (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2024-01-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Depresivni poremećaj je među vodećim poremećajima koji uzrokuju pad kvalitete života, radne i socijalne funkcionalnosti, a oko 30 % oboljelih ima terapijski rezistentni depresivni poremećaj (TRDP). Terapija svjetlom se kao dodatna metoda primjenjuje u liječenju TRDP-a. Do sada nisu ispitivani moždani neurotrofni čimbenik (BDNF) i interleukin-6 (IL-6) kao periferni pokazatelji djelovanja fototerapije. Rezultati istraživanja u koje je bilo uključeno 60 ženskih ispitanika ukazuju da nakon 4 tjedna fototerapije nema značajne promjene u koncentracijama BDNF-a u plazmi i IL-6 u serumu, kao i da poboljšanje depresivnih simptoma nije u korelaciji s promjenama koncentracija BDNF-a i IL-6. Ispitanice koje su prema ocjenskim ljestvicama HAMD-17 i MADRS dobro odgovorile na fototerapiju ili su postigle remisiju, imale su veći porast perifernih koncentracija BDNF-a i IL-6, u odnosu na one koje nisu dobro odgovorile. Istraživanje je pridonijelo boljem razumijevanju djelovanja fototerapije i njene primjene kod TRDP-a, što otvara dodatne mogućnosti za buduće studije.

Abstract (english)

Depressive disorder is among the leading disorders that cause a decline in quality of life, work and social functionality, and about 30 % of patients have treatment-resistant depression (TRD). Light therapy is used as an additional method in the treatment of TRD. So far, brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) have not been investigated as peripheral indicators of the effect of phototherapy. The results of the research involving 60 female subjects indicate that there is no significant change in plasma levels of BDNF and serum levels of IL-6 after 4 weeks of phototherapy, as well as that the improvement of depressive symptoms is not correlated with the changes in levels of BDNF and IL-6. Subjects who, according to the HAMD-17 and MADRS rating scales, responded well to phototherapy or achieved remission, had a greater increase in peripheral levels of BDNF and IL-6 compared to those who did not respond well. The research contributed to a better understanding of the effect of phototherapy and its application in TRD, which opens additional opportunities for future studies.

• Keywords: terapija svjetlom; terapijski rezistentni depresivni poremećaj; BDNF; IL-6
• Keywords (english): light therapy; treatment-resistant depression; BDNF; IL-6
• Language: croatian
• URN:NBN: urn:nbn:hr:105:484531
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 140 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-01-19 08:51:58