Ekvivalent: Trendovi učestalosti i smrtnosti od karcinoma štitnjače u Hrvatskoj u razdoblju od 1988. do 2010. godine

professional thesis

• Title (english): Equivalent: Thyroid Cancer Incidence and Mortality Trends in Croatia 1988-2010
• Author: Luka Vučemilo
• Mentor: Mario Šekerija (mentor)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2023-07-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract

Cilj ovoga rada bio je opisati i protumačiti trendove incidencije i smrtnosti karcinoma štitnjače u Hrvatskoj u razdoblju od 1988. do 2010. godine, usporediti ih s trendovima u drugim zemljama te odrediti udio histoloških tipova karcinoma štitnjače i njihov utjecaj na trendove. Koristeći podatke iz Registra za rak Hrvatske i iz baze podataka Svjetske zdravstvene organizacije učinjena je regresijska analiza uz pomoć točaka spajanja za procjenu trendova incidencije i smrtnosti. Incidencija karcinoma štitnjače porasla je i kod žena i kod muškaraca u promatranom razdoblju s procijenjenim godišnjim postotkom promjene (engl. estimated annual percent change, EAPC) od 6,4% i 5,5%, bez identificiranih točaka spajanja. Kod žena je zabilježen značajan pad smrtnosti (EAPC -2,1%), dok se kod muškaraca smrtnost smanjila, ali statistički neznačajno (EAPC -1,3%). Statistički značajan porast incidencije zabilježen je samo kod papilarnih karcinoma s godišnjim postotkom promjene od 6,7% za žene i 7,9% za muškarce. Incidencija karcinoma štitnjače porasla je u promatranom razdoblju uz stalan i umjeren pad smrtnosti kod žena te uz statistički neznačajan pad smrtnosti kod muškaraca. Incidencija karcinoma štitnjače je porasla zbog porasta broja papilarnih karcinoma, što je također utjecalo na pad smrtnosti od karcinoma štitnjače kod žena. Zabilježeni trendovi su slični trendovima u drugim europskim zemljama i zahtijevaju dodatnu analizu svih čimbenika koji na njih utječu.

Abstract (english)

The aim of our study was to describe and interpret national trends in thyroid cancer in Croatian men and women during the 1988-2010 period, to better understand the incidence and mortality trends in comparison with other populations, and to determine the proportion of certain histologic subtypes of thyroid cancer and their impact on these trends. Using information
from the Croatian National Cancer Registry and WHO Mortality Database, we estimated trends in the age-standardized incidence and mortality rates by joinpoint regression analysis. Thyroid cancer incidence increased in both women and men during the study period, with the estimated annual percent change (EAPC) of 6.4% and 5.5%, with no joinpoints identified. A significant decrease in mortality (EAPC -2.1%) was observed in women, while in men mortality rates decreased nonsignificantly (EAPC -1.3%). A statistically significant incidence increase was observed only for papillary carcinomas with annual incidence increase by 6.7% for women and 7.9% for men. During the study period, thyroid cancer showed an incidence increase in Croatia with persistent and steady decrease in mortality in women and statistically nonsignificant decrease in mortality in men. The increase in papillary carcinomas led to the thyroid cancer incidence increase and also affected the thyroid cancer mortality decrease in women. The trends observed are similar to those in other European countries and require additional analysis to determine all factors that have an effect on them

• Keywords: Štitnjača; tumori – epidemiologija; Štitnjača; tumori – trendovi; Hrvatska
• Keywords (english): hyroid neoplasms – epidemiology; Thyroid neoplasms – trends; Croatia
• Language: english
• URN:NBN: urn:nbn:hr:105:236460
• Study programme: Title: Otorhinolaryngology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/magistra otorinolaringologije (sveučilišni/a magistar/magistra otorinolaringologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-02-05 09:50:13