Clinical and immunopathological characteristics of autoimmune blistering skin diseases

Scientific paper - Review paper

• Author: Anita Gunarić
• Author: Dubravka Šimić
• Author: Branka Marinović
• Author's institution: University of Zagreb; School of Medicine; (Department of Dermatology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract (english)

Autoimmune blistering skin diseases (AIBDs) encompass several heterogeneous conditions clinically characterized by blisters and erosions on the skin and mucous membranes and are immunopathologically characterized by autoantibodies against structural proteins of the skin. Those proteins are responsible for the intercellular contact between epidermal keratinocytes and adhesion of the basal keratinocytes to the dermis. Therefore, AIBDs are divided into two main groups: intraepidermal (the pemphigus group) and subepidermal (the pemphigoid) groups. The diagnostic methods for AIBDs have made tremendous progress in the last 2 decades due to the availability of standardized serological assays that allow precise diagnosis in most patients. If left untreated, these diseases are potentially life-threatening due to superinfections and loss of body fluids, and in some severe cases due to restricted food intake. Based on the available literature, this paper provides an overview of the clinical and immunopathological characteristics of the most common AIBDs.

• Keywords (english): Autoantibodies; Autoimmune Diseases / diagnosis; Blister; Humans; Pemphigoid, Bullous / diagnosis; Pemphigoid, Bullous / pathology; Pemphigus / diagnosis
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Acta Dermatovenerologica Alpina Pannonica et Adriatica
• Numbering: vol. 32, no. 4, pp. 141-149
• e-ISSN: 1318-4458
• DOI: https://doi.org/10.15570/actaapa.2023.27
• URN:NBN: urn:nbn:hr:105:788179
• Publication: 2023-12-30
• Document URL: http://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2023.27/actaapa.2023.27.pdf
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-04 10:02:59