prikaz prve stranice dokumenta Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep
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Scientific paper - Original scientific paper
Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep
Scientific Reports, 13 (2023), 1; 22079. https://doi.org/10.1038/s41598-023-48878-9
Ivanjko, Natalia; Štoković, Nikola; Pećin, Marko; Vnuk, Dražen; Smajlović, Ana; Ivkić, Niko; Capak, Hrvoje; Javor, Ana; Vrbanac, Zoran; Matičić, Dražen; Vukičević, Slobodan

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Ivanjko, N., Štoković, N., Pećin, M., Vnuk, D., Smajlović, A., Ivkić, N. ... Vukičević, S. (2023). Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep. Scientific Reports, 13. (1). doi: 10.1038/s41598-023-48878-9

Ivanjko, Natalia, et al. "Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep." Scientific Reports, vol. 13, no. 1, 2023. https://doi.org/10.1038/s41598-023-48878-9

Ivanjko, Natalia, Nikola Štoković, Marko Pećin, Dražen Vnuk, Ana Smajlović, Niko Ivkić, Hrvoje Capak, et al. "Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep." Scientific Reports 13, no. 1 (2023). https://doi.org/10.1038/s41598-023-48878-9

Ivanjko, N., et al. (2023) 'Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep', Scientific Reports, 13(1). doi: 10.1038/s41598-023-48878-9

Ivanjko N, Štoković N, Pećin M, Vnuk D, Smajlović A, Ivkić N, and sur.. Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep. Scientific Reports [Internet]. 2023 December 12 [cited 2025 February 02];13(1). doi: 10.1038/s41598-023-48878-9

N. Ivanjko, et al., "Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep", Scientific Reports, vol. 13, no. 1, December 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:755985. [Accessed: 02 February 2025]

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Metadata
Title (english)Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep
AuthorNatalia Ivanjko
AuthorNikola Štoković
AuthorMarko Pećin
AuthorDražen Vnuk
AuthorAna Smajlović
AuthorNiko Ivkić
AuthorHrvoje Capak
AuthorAna Javor
AuthorZoran Vrbanac
AuthorDražen Matičić
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
Posterolateral spinal fusion (PLF) is a procedure used for the treatment of degenerative spine disease. In this study we evaluated Osteogrow-C, a novel osteoinductive device comprised of recombinant human Bone morphogenetic protein 6 (rhBMP6) dispersed in autologous blood coagulum with synthetic ceramic particles, in the sheep PLF model. Osteogrow-C implants containing 74-420 or 1000-1700 µm ceramic particles (TCP/HA 80/20) were implanted between L4-L5 transverse processes in sheep (Ovis Aries, Merinolaandschaf breed). In the first experiment (n = 9 sheep; rhBMP6 dose 800 µg) the follow-up period was 27 weeks while in the second experiment (n = 12 sheep; rhBMP6 dose 500 µg) spinal fusion was assessed by in vivo CT after 9 weeks and at the end of the experiment after 14 (n = 6 sheep) and 40 (n = 6 sheep) weeks. Methods of evaluation included microCT, histological analyses and biomechanical testing. Osteogrow-C implants containing both 74-420 and 1000-1700 µm ceramic particles induced radiographic solid fusion 9 weeks following implantation. Ex-vivo microCT and histological analyses revealed complete osseointegration of newly formed bone with adjacent transverse processes. Biomechanical testing confirmed that fusion between transverse processes was complete and successful. Osteogrow-C implants induced spinal fusion in sheep PLF model and therefore represent a novel therapeutic solution for patients with degenerative disc disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 13, no. 1, 22079
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-023-48878-9
URN:NBNurn:nbn:hr:105:755985
Publication2023-12-12
Document URLhttps://www.nature.com/articles/s41598-023-48878-9
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-03-05 08:33:27