prikaz prve stranice dokumenta A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning
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Scientific paper - Original scientific paper
A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning
Acta Biochimica Polonica, 58 (2011), 2; 193-198. urn:nbn:hr:105:126735
Lovrić, Jasna; Berend, Suzana; Lucić Vrdoljak, Ana; Radić, Božica; Katalinić, Maja; Kovarik, Zrinka; Želježić, Davor; Kopjar, Nevenka; Rast, Slavko; Mesić, Milan

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Lovrić, J., Berend, S., Lucić Vrdoljak, A., Radić, B., Katalinić, M., Kovarik, Z. ... Mesić, M. (2011). A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning. Acta Biochimica Polonica, 58. (2), 193-198. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:126735

Lovrić, Jasna, et al. "A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning." Acta Biochimica Polonica, vol. 58, no. 2, 2011, pp. 193-198. https://urn.nsk.hr/urn:nbn:hr:105:126735

Lovrić, Jasna, Suzana Berend, Ana Lucić Vrdoljak, Božica Radić, Maja Katalinić, Zrinka Kovarik, Davor Želježić, Nevenka Kopjar, Slavko Rast and Milan Mesić. "A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning." Acta Biochimica Polonica 58, no. 2 (2011): 193-198. https://urn.nsk.hr/urn:nbn:hr:105:126735

Lovrić, J., et al. (2011) 'A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning', Acta Biochimica Polonica, 58(2), pp. 193-198. Available at: https://urn.nsk.hr/urn:nbn:hr:105:126735 (Accessed 02 May 2024)

Lovrić J, Berend S, Lucić Vrdoljak A, Radić B, Katalinić M, Kovarik Z, and sur.. A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning. Acta Biochimica Polonica [Internet]. 2011 [cited 2024 May 02];58(2):193-198. Available at: https://urn.nsk.hr/urn:nbn:hr:105:126735

J. Lovrić, et al., "A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning", Acta Biochimica Polonica, vol. 58, no. 2, pp. 193-198, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:126735. [Accessed: 02 May 2024]

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Metadata
Title (english)A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning
AuthorJasna Lovrić
AuthorSuzana Berend
AuthorAna Lucić Vrdoljak
AuthorBožica Radić
AuthorMaja Katalinić
AuthorZrinka Kovarik
AuthorDavor Želježić
AuthorNevenka Kopjar
AuthorSlavko Rast
AuthorMilan Mesić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
A conjugate of pyridine-4-aldoxime and atropine (ATR-4-OX) was synthesized and its antidotal efficiency was tested in vitro on tabun- or paraoxon-inhibited acetylcholinesterase (AChE) of human erythrocytes as well as in vivo using soman-, tabun- or paraoxon-poisoned mice. Its genotoxic profile was assessed on human lymphocytes in vitro and was found acceptable for further research. ATR-4-OX showed very weak antidotal activity, inadequate for soman or tabun poisoning. Conversely, it was effective against paraoxon poisoning both in vitro and in vivo. All animals treated with 5 % or 25 % LD(50) doses of the new oxime survived after administration of 10.0 or 16.0 LD(50) doses of paraoxon, respectively. Based on the persistence of toxicity symptoms in mice, the atropine moiety had questionable effects in attenuating such symptoms. It appears that ATR-4-OX has a therapeutic effect related to the reactivation of phosphylated AChE, but not to receptor antagonization.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Biochimica Polonica
Numberingvol. 58, no. 2, pp. 193-198
p-ISSN0001-527X
URN:NBNurn:nbn:hr:105:126735
Publication2011
Document URLhttp://www.actabp.pl/pdf/2_2011/193.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:03:43