The influence of the different morphological changes on gastric mucosa on somatostatin cell number in antrum mucosa and serum somatostatin

Scientific paper - Original scientific paper

• Title (croatian): Utjecaj različitih morfoloških promjena želučane sluznice na broj somatostatinskih stanica u sluznici antruma želuca i vrijednosti somatostatina u serumu
• Author: Silvio Mihaljević
• Author: Miroslava Katičić
• Author: Željko Krznarić
• Author: Branko Dmitrović
• Author: Ivan Karner
• Author: Mario Štefanić
• Author: Ljerka Pinotić
• Author: Marina Samardžija
• Author: Mirta Benšić
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

The aim of our paper was to investigate the influence of the different morphological changes on gastric mucosa on somatostatin D-cell number in antral mucosa and serum Somatostatin. We analyzed according to Sydney classification to what extent the severity of gastritis affect the observed hormonal values. somatostatin D-cell number in antral mucosa and serum Somatostatin values were compared between three groups of patients; mild, moderate and severe chronic gastritis. The average number of somatostatin cell in biopsy sample of antrum mucosa was 30.41 +/- 35.38 (N = 17) in the case of middle form, 18.69 +/- 26.65 (N = 56) in moderate and in severe case of chronic gastritis 5.23 +/- 5.93 (N = 7) cells in mm2 of mucosa. The level of somatostatin in the serum of middle form gastritis were 26.43 +/- 28.76, moderate 19.95 +/- 35.93 and severe 17.88 +/- 17.66 pg/mL. In order to determine the number of somatostatin cells in antrum mucosa and serum somatostatin with present morphological changes of mucosa, it might helpful to exclude the patients with non-ulcer dyspepsia, but with the higher risk of premalignant and malignant changes.

Abstract (croatian)

U ovom radu istražili smo utjecaj različitih morfoloških promjena želučane sluznice na broj somatostatinskih D
stanica sluznice antruma želuca i serumski somatostatin. Prema Sydnejskoj klasifikaciji gastritisa analizirali smo koliko
jačina upalnih promjena sluznice želuca utječe na promatrane vrijednosti hormona. Broj somatostatinskih D stanica
u sluznici antruma želuca i vrijednosti serumskog somatostatina uspoređivali smo kod tri grupe pacijenata: s blagim,
umjerenim i teškim kroničnim gastritisom. Prosječni broj somatostatinskih stanica u bioptičkom uzorku sluznice antruma
bio je 30,41±35,38 (N=17) u blagom gastritisu, 18,69±26,65 (N=56) u umjereno teškom i 5,23±5,93 (N=7) stanica
umm2 sluznice. Vrijednosti serumskog somatostatina u blagom gastritisu bile su 26,43±28,76, umjerenom 19,95±35,93
i teškom obliku 17,88±17,66 pg/mL. Određivanje broja somatostatinskih stanica sluznice antruma želuca i serumskog
somatostatina kod određenih morfoloških promjena želučane sluznice može nam pomoći da izdvojimo pacijente s neulkusnom
dispepsiom te one koji imaju veliki rizik od razvoja premalignih i malignih promjena.

• Keywords (english): Cohort Studies; Gastric Mucosa/cytology; Gastric Mucosa/pathology; Gastritis/blood; Gastritis/pathology; Humans; Somatostatin/blood; Somatostatin-Secreting Cells/cytology; Somatostatin-Secreting Cells/pathology
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 35, no. 1, pp. 5-8
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:293979
• Publication: 2011-03
• Document URL: https://hrcak.srce.hr/64721
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:05:50