prikaz prve stranice dokumenta Gene polymorphisms of the renin-angiotensin system and early development of hypertension
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Scientific paper - Original scientific paper
Gene polymorphisms of the renin-angiotensin system and early development of hypertension
American Journal of Hypertension, 19 (2006), 8; 837-842. https://doi.org/10.1016/j.amjhyper.2006.01.004
Barbalić, Maja; Škarić-Jurić, Tatjana; Cambien, François; Barbaux, Sandrine; Poirier, Odette; Turek, Stjepan; Vrhovski-Hebrang, Danijela; Čubrilo-Turek, Mirjana; Rudan, Igor; Rudan, Pavao; Smolej-Narančić, Nina

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Barbalić, M., Škarić Jurić, T., Cambien, F., Barbaux, S., Poirier, O., Turek, S. ... Smolej Narančić, N. (2006). Gene polymorphisms of the renin-angiotensin system and early development of hypertension. American Journal of Hypertension, 19. (8), 837-842. doi: 10.1016/j.amjhyper.2006.01.004

Barbalić, Maja, et al. "Gene polymorphisms of the renin-angiotensin system and early development of hypertension." American Journal of Hypertension, vol. 19, no. 8, 2006, pp. 837-842. https://doi.org/10.1016/j.amjhyper.2006.01.004

Barbalić, Maja, Tatjana Škarić Jurić, François Cambien, Sandrine Barbaux, Odette Poirier, Stjepan Turek, Danijela Vrhovski Hebrang, et al. "Gene polymorphisms of the renin-angiotensin system and early development of hypertension." American Journal of Hypertension 19, no. 8 (2006): 837-842. https://doi.org/10.1016/j.amjhyper.2006.01.004

Barbalić, M., et al. (2006) 'Gene polymorphisms of the renin-angiotensin system and early development of hypertension', American Journal of Hypertension, 19(8), pp. 837-842. doi: 10.1016/j.amjhyper.2006.01.004

Barbalić M, Škarić Jurić T, Cambien F, Barbaux S, Poirier O, Turek S, and sur.. Gene polymorphisms of the renin-angiotensin system and early development of hypertension. American Journal of Hypertension [Internet]. 2006 August [cited 2024 December 01];19(8):837-842. doi: 10.1016/j.amjhyper.2006.01.004

M. Barbalić, et al., "Gene polymorphisms of the renin-angiotensin system and early development of hypertension", American Journal of Hypertension, vol. 19, no. 8, pp. 837-842, August 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:196637. [Accessed: 01 December 2024]

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Metadata
Title (english)Gene polymorphisms of the renin-angiotensin system and early development of hypertension
AuthorMaja Barbalić
AuthorTatjana Škarić-Jurić
AuthorFrançois Cambien
AuthorSandrine Barbaux
AuthorOdette Poirier
AuthorStjepan Turek
AuthorDanijela Vrhovski-Hebrang
AuthorMirjana Čubrilo-Turek
AuthorIgor Rudan
AuthorPavao Rudan
AuthorNina Smolej-Narančić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension. ----- METHODS: One hundred nineteen hypertensive and 125 normotensive participants aged 18 to 40 years were selected from a broader sample representative of the general population of Croatia. The selection criteria for hypertensive cases were systolic blood pressure (BP) higher than 140 mm Hg or diastolic BP higher than 90 mm Hg and a history of hypertension according to patient interview. ----- RESULTS: Among the polymorphisms investigated, only those located on the ACE gene were associated with hypertension. For ACE I/D, the odds ratio for hypertension of DD versus II homozygote individuals was 2.50 (95% confidence interval [CI] 1.19-5.25) and for ACE T-3892C, the odds ratio of CC versus TT individuals was 2.32 (95% CI 1.05-5.10). Both polymorphisms of the ACE gene were in tight linkage disequilibrium. Of the investigated risk factors for hypertension, only body mass index (BMI) showed an influence on the early development of hypertension, acting independently of the ACE polymorphism. Their additive effect gives rise to 86% of hypertensives in subjects having both the DD genotype and BMI >or=30 kg/m(2). ----- CONCLUSIONS: The present study provides evidence of the association of the ACE gene polymorphisms and premature hypertension. In addition, BMI proved to be another important predictor of the disorder acting independently of the ACE gene.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleAmerican Journal of Hypertension
Numberingvol. 19, no. 8, pp. 837-842
p-ISSN0895-7061
DOIhttps://doi.org/10.1016/j.amjhyper.2006.01.004
URN:NBNurn:nbn:hr:105:196637
Publication2006-08
Document URLhttps://doi.org/10.1016/j.amjhyper.2006.01.004
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:08:23