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Scientific paper - Review paper
Genes associated with multiple sclerosis: 15 and counting
Expert Review of Molecular Diagnostics, 10 (2010), 7; 857-861. https://doi.org/10.1586/erm.10.77
Habek, Mario; Brinar, Vesna V.; Borovečki, Fran

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Habek, M., Brinar, V. V. & Borovečki, F. (2010). Genes associated with multiple sclerosis: 15 and counting. Expert Review of Molecular Diagnostics, 10. (7), 857-861. doi: 10.1586/erm.10.77

Habek, Mario, et al. "Genes associated with multiple sclerosis: 15 and counting." Expert Review of Molecular Diagnostics, vol. 10, no. 7, 2010, pp. 857-861. https://doi.org/10.1586/erm.10.77

Habek, Mario, Vesna V. Brinar and Fran Borovečki. "Genes associated with multiple sclerosis: 15 and counting." Expert Review of Molecular Diagnostics 10, no. 7 (2010): 857-861. https://doi.org/10.1586/erm.10.77

Habek, M., Brinar, V. V. and Borovečki, F. (2010) 'Genes associated with multiple sclerosis: 15 and counting', Expert Review of Molecular Diagnostics, 10(7), pp. 857-861. doi: 10.1586/erm.10.77

Habek M, Brinar VV, Borovečki F. Genes associated with multiple sclerosis: 15 and counting. Expert Review of Molecular Diagnostics [Internet]. 2010 October [cited 2024 December 19];10(7):857-861. doi: 10.1586/erm.10.77

M. Habek, V. V. Brinar and F. Borovečki, "Genes associated with multiple sclerosis: 15 and counting", Expert Review of Molecular Diagnostics, vol. 10, no. 7, pp. 857-861, October 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:714944. [Accessed: 19 December 2024]

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Metadata
Title (english)Genes associated with multiple sclerosis: 15 and counting
AuthorMario Habek
AuthorVesna V. Brinar
AuthorFran Borovečki
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Evaluation of: The International Multiple Sclerosis Genetics Consortium (IMSGC). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun. 11(5), 397-405 (2010). Multiple sclerosis (MS) develops in genetically susceptible populations as a result of environmental exposures, and discovering these genetic and/or environmental factors will provide fundamental new insights into the pathogenesis, diagnosis and treatment of this disabling disease. With the introduction of genome-wide association studies, the number of genes found to be associated with MS has increased rapidly. In all of these genes, in a study by the International Multiple Sclerosis Genetics Consortium, the classic MS risk locus, HLA-DRB1, stood out with remarkably strong statistical significance, but they also identified 12 other loci and/or genes associated with MS. However, all of these alleles have a very modest odds ratio and they explain approximately 3% of the variance in MS risk. Recently, the International Multiple Sclerosis Genetics Consortium provided evidence for three new loci that show significant association at a genome-wide level: RGS1, IL12A and MPHOSPH9/CDK2AP1. In this article, we will review the three newly discovered susceptibility loci and the implications of genome-wide association studies in MS on clinical practice.
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleExpert Review of Molecular Diagnostics
Numberingvol. 10, no. 7, pp. 857-861
p-ISSN1473-7159
DOIhttps://doi.org/10.1586/erm.10.77
URN:NBNurn:nbn:hr:105:714944
Publication2010-10
Document URLhttps://doi.org/10.1586/erm.10.77
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:11:16