Hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CS) as treatment of peritoneal carcinomatosis: preliminary results in Croatia

Professional paper - Review paper

• Title (croatian): Hipertermička intraperitonealna kemoterapija (HIPEC) i citoreduktivna kirurgija (CS) kao terapija za peritonealni tumor: preliminarni rezultati iz Hrvatske
• Author: Mate Majerović
• Author: Darko Milinović
• Author: Slavko Orešković
• Author: Petar Matošević
• Author: Mirjana Mirić
• Author: Tihomir Kekez
• Author: Emil Kinda
• Author: Goran Augustin
• Author: Hrvoje Silovski
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

The purpose of our study was to evaluate initial results following introduction of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Cytoreductive Surgery (CS). Twenty two patients with intraperitoneal malignancy undergone cytoreductive surgery (CS) and hyperthermic intraoperative chemotherapy (HIPEC) between January of 2007 and January 2010. Nine patients had adenocarcinoma of colorectal origin, 8 patients had ovarian cancer, and 5 had pseudomyxoma peritonei. Inclusion criteria were diagnosis of peritoneal carcinomatosis based on intraoperative assessment during first operative procedure for intraabdominal malignancy or follow-up diagnostic imaging proof Excluded were patients with known malignant proliferation outside abdomen, liver metastasis and ASA score 4 and higher. All patients with pseudomyxoma peritonei diagnosis are alive, with mean follow-up time 24.8 months (range 15-35). In group of patients with adenocarcinoma from colorectal origin, 3 died, resulting in mean survival time 7.6 months (range 1-16). In group of patients with ovarian cancer, 2 died, resulting in mean survival time 13.8 months (range 0-31). Two patients died in early postoperative period. Most of the patients had some sort of mental disorder. Although HIPEC with CS improves survival, during introduction period higher morbidity and mortality could be expected.

Abstract (croatian)

Svrha našeg istraživanja bila je iznijeti naše početne rezultate hipertermijske intraperitonealne kemoterapije
(HIPEC) i citoreduktivne kirurgije (CS). Istraživanjem je obuhvaćeno 22 bolesnika s karcinozom peritoneuma ili primarnom
zloćudnom tvorbom peritoneuma, u razdoblju od siječnja 2007. do siječnja 2010. Devet bolesnika imalo je
adenokarcinom kolona kao primarni tumor, osam bolesnika karcinom jajnika, a pet pseudomiksom peritoneuma. Kriteriji
za odabir bolesnika pogodnih za ovaj operativni zahvat bili su dijagnoza karcinomatoze peritoneuma za vrijeme
prve operacije zbog maligne bolesti ili dijagnoza proširene intraperitonealne maligne bolesti na temelju radiološke obrade.
Isključeni su bolesnici s prijeoperacijski poznatom proširenom malignom bolesti van abdomena, s metastazama
jetre, i bolesnici čiji je anesteziološki rizik za operaciju bio ASA stadij 4 i više. Bolesnici s pseudomiksomom peritoneuma
imali su srednje vrijeme praćenja 24,8 mjeseci (raspon 15–35), i do kraja praćenog razdoblja bili su svi živi. U
skupini bolesnika s adenokarcinom kolona, troje je umrlo, što je rezultiralo srednjim vremenom preživljenja 7,6 mjeseci
(raspon 1–16). U skupini bolesnika s karcinom jajnika, dvije bolesnice su umrle, što je rezultiralo srednjim vremenom
preživljenja 13,8 mjeseci (raspon 0–31). Dvoje bolesnika umrlo je u ranom poslijeoperacijskom razdoblju. Većina bolesnika
imala je poslijeoperacijski promjene psihološkog statusa određenog stupnja, najviše u vidu depresivnog sindroma.
Iako HIPEC sa CS poboljšava preživljenje navedenih skupina bolesnika, tijekom razdoblja učenja ovog novog tipa
operativnog zahvata može se očekivati veći morbiditet i mortalitet. Ranije upućivanje bolesnika u odabrane tercijarne
ustanove vjerojatno bi pridonijelo smanjenju morbiditeta i mortaliteta.

• Keywords (english): Adult; Aged; Antineoplastic Agents/administration & dosage; Combined Modality Therapy; Female; Humans; Hyperthermia, Induced/methods; Male; Middle Aged; Peritoneal Neoplasms/mortality; Peritoneal Neoplasms/therapy
• Language: english
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 35, no. 4, pp. 1349-1352
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:484884
• Publication: 2011-12
• Document URL: http://hrcak.srce.hr/file/112426
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:25:01