Quantitative analysis of troponin I serum values in patients with acute cholecystitis

Scientific paper - Original scientific paper

• Title (croatian): Kvantitativna analiza serumskog troponina i u bolesnika s akutnom upalom žučnjaka
• Author: Žarko Babić
• Author: Zoran Bogdanović
• Author: Zdravko Dorosulić
• Author: Merita Basha
• Author: Željko Krznarić
• Author: Ivo Sjekavica
• Author: Milan Kujundžić
• Author: Mario Tadić
• Author: Marko Banić
• Author: Vjekoslav Jagić
• Author: Marinko Marušić
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

The diagnosis and staging of acute cholecystitis, upon a lot of diagnostic methods and some scoring systems, is still a great clinical problem. The aim of the study was to investigate if serum Troponin I is elevated in patients with acute cholecystitis. Following informed consent, 65 patients with clinical and laboratory signs of acute cholecystitis were enrolled. All patients had measured serum Troponin I level and an abdominal ultrasound was done before definitive treatment was performed. Increased serum Troponin I level was found in most patients with severe form of acute cholecystitis (p < 0.00001). It reached sensitivity of 94.5% and specificity of 57.1% of this test. In multiple regression analysis Troponin I significantly correlated (p < 0.05) with the serum aspartate aminotransferase (r = 0.27), gamma-glutamyl transferase (r = 0.25) and gallbladder wall (> 6 mm) thickness (r = 0.58). Our study confirms that in most patients with severe and acute cholecystitis, serum Troponin I is increased. Troponin I level is in a lower range than it would be in patients with cardiac muscle damage or necrosis. Measuring serum Troponin I is a fast, reliable and widely performed test that could, with other routinely measured parameters, help in early diagnosis of the severe form of acute cholecystitis.

Abstract (croatian)

Dijagnozu i stupnjevanje akutne upale žučnjaka i dalje je, unatoč brojnim dijagnostičkim metodama, ostao težak
zadatak. Cilj ovog rada bio je istražiti ulogu povišenih serumskih vrijednosti Troponina I u bolesnika s akutnim kolecistitisom.
Nakon informiranog pristanka u studiju smo uključili 65 bolesnika s kliničkim i laboratorijskim znakovima
akutne upale žučnjaka. Svim bolesnicima je mjerena razina serumskog Troponina I te im je učinjen i transabdominalni
ultrazvuk prije početka liječenja. U većine bolesnika s teškim oblikom akute upale žučnjaka nađene su povišene vrijednosti
Troponina I (p<0,00001). Postigli smo osjetljivost testa od 94,5% i specifičnost testa od 57,1%. Testom multiple
regresije statistički značajnija korelacija (p<0,05) postignuta je za Troponin I, za serumsku aspart aminotransferazu
(r=0,27), gamaglutamil transferazu (r=0,25) i za debljinu stjenke žučnjaka (>6 mm) (r=0,58). Naša studija potvrđuje
da je većina bolesnika s teškim oblikom akutne upale žučnjaka imala povišene vrijednosti Troponina, ali u vrijednostima
koje nisu karakteristične za oštećenje ili nekrozu srčanog mišića. Mjerenje Troponina I brza je i široko primjenjiva metoda
koja uz ostale rutinske parametre može pomoći u dijagnostici i stupnjevanju teških oblika akutne upale žučnjaka.

• Keywords (english): Adult; Aged; Aged, 80 and over; Biomarkers / blood; Cholecystitis, Acute / blood; Cholecystitis, Acute / diagnosis; Female; Humans; Male; Middle Aged; Sensitivity and Specificity; Severity of Illness Index; Troponin I / blood
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 36, no. 1, pp. 145-150
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:767004
• Publication: 2012-03
• Document URL: https://hrcak.srce.hr/78804
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:28:29