prikaz prve stranice dokumenta Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking
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Scientific paper - Original scientific paper
Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking
Neuroscience Letters, 520 (2012), 1; 67-70. https://doi.org/10.1016/j.neulet.2012.05.032
Babić, Mirjana; Nedić, Gordana; Muck-Šeler, Dorotea; Borovečki, Fran; Pivac, Nela

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Babić, M., Nedić, G., Muck Šeler, D., Borovečki, F. & Pivac, N. (2012). Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking. Neuroscience Letters, 520. (1), 67-70. doi: 10.1016/j.neulet.2012.05.032

Babić, Mirjana, et al. "Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking." Neuroscience Letters, vol. 520, no. 1, 2012, pp. 67-70. https://doi.org/10.1016/j.neulet.2012.05.032

Babić, Mirjana, Gordana Nedić, Dorotea Muck Šeler, Fran Borovečki and Nela Pivac. "Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking." Neuroscience Letters 520, no. 1 (2012): 67-70. https://doi.org/10.1016/j.neulet.2012.05.032

Babić, M., et al. (2012) 'Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking', Neuroscience Letters, 520(1), pp. 67-70. doi: 10.1016/j.neulet.2012.05.032

Babić M, Nedić G, Muck Šeler D, Borovečki F, Pivac N. Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking. Neuroscience Letters [Internet]. 2012 June 27 [cited 2025 March 15];520(1):67-70. doi: 10.1016/j.neulet.2012.05.032

M. Babić, G. Nedić, D. Muck Šeler, F. Borovečki and N. Pivac, "Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking", Neuroscience Letters, vol. 520, no. 1, pp. 67-70, June 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:306340. [Accessed: 15 March 2025]

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Metadata
Title (english)Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking
AuthorMirjana Babić
AuthorGordana Nedić
AuthorDorotea Muck-Šeler
AuthorFran Borovečki
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Nicotine addiction, related to cigarette smoking, develops as a product of the complex interactions between social, environmental and genetic factors. Genes encoding the components of the dopaminergic system are thought to be associated with smoking. Literature data showed not only an association, but also a lack of association between variable number of tandem repeats (VNTR) polymorphism located in the third exon of dopamine D4 receptor (DRD4) gene and smoking. Repetitive sequence of DRD4 VNTR is 48 bp long and maximum 11 tandem copies were reported in humans. Presence of alleles with 6 and more repeats (i.e. long alleles) was associated with greater tendency to novelty seeking and addictive behaviors than the presence of 5 and less alleles (short alleles). The aim of this study was to determine the association between VNTR in DRD4 gene and present smoking status in ethnically homogenous Caucasian population from the Eastern European (Croatian) origin. Genotyping was done in 565 healthy subjects, 511 men and 54 women, respectively, who were subdivided into 176 smokers and 389 nonsmokers. Logistic regression analyses, adjusted for age and sex, revealed the lack of significant (p>0.05) effect of the 4/4, 4/7 and 7/7 genotypes, or carriers of the long and short allele, or all genotypes of the DRD4 VNTR on smoking status. The results of this study failed to confirm the hypothesis that long allele of the DRD4 VNTR is associated with smoking status in Caucasian subjects.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleNeuroscience Letters
Numberingvol. 520, no. 1, pp. 67-70
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2012.05.032
URN:NBNurn:nbn:hr:105:306340
Publication2012-06-27
Document URLhttps://doi.org/10.1016/j.neulet.2012.05.032
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:31:04